Article
|
Open Access
Featured
-
-
Article
| Open AccessGata6+ resident peritoneal macrophages promote the growth of liver metastasis
GLPMs represent a population of fetal liver derived large peritoneal cavity Gata6+ macrophages, with the capacity to invade the tissues they surround. Here, in experimental colon cancer liver metastasis models, the authors show that GLPMs invade liver metastasis directly from the peritoneum, promoting liver metastases growth.
- Mokarram Hossain
- , Raymond Shim
- & Paul Kubes
-
Article
| Open AccessGenetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury
Body cavity macrophages reside on the serous surfaces of organs and believed to participate in organ repair following injury. Here the authors show with a fate-mapping reporter system that these cells, although accumulate at the surfaces of injured liver or lung, don’t penetrate deeply into the tissue.
- Hengwei Jin
- , Kuo Liu
- & Bin Zhou
-
Article
| Open AccessCell barrier function of resident peritoneal macrophages in post-operative adhesions
Peritoneal adhesions are a major cause of complications after abdominal surgery. Here the authors use a post-operative abdominal adhesion model in mice to show that resident F4/80HighCD206− macrophages form a protective barrier that can be enhanced by IL-4 administration or adoptive transfer of these cells.
- Tomoya Ito
- , Yusuke Shintani
- & Ken Suzuki
-
Article
| Open AccessRecruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
The peritoneal cavity is a complicated myeloid niche containing a mixed population of resident macrophages and infiltrating cells that are responsive to inflammatory cues. Here the authors trace the fate of these infiltrating macrophages, their conversion to resident cells and how this is altered by the local inflammatory state over time.
- P. A. Louwe
- , L. Badiola Gomez
- & S. J. Jenkins
-
Article
| Open AccessRXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression
Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs.
- María Casanova-Acebes
- , María Piedad Menéndez-Gutiérrez
- & Mercedes Ricote
-
Article
| Open AccessSympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A
Diverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance molecule A signalling.
- Andreas Körner
- , Martin Schlegel
- & Valbona Mirakaj
-
Article
| Open AccessDiverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.
- Gregory J. Fonseca
- , Jenhan Tao
- & Christopher K. Glass
-
Article
| Open AccessHuman in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
Cross-presentation, or the presentation of exogenous antigens on MHC-I, is thought to be restricted to dendritic cells (DCs). Here the authors show that human DCs and macrophages developed in vivo from monocytes can both perform cross-presentation using a non-conventional pathway, but only DCs are capable of inducing cytotoxic CD8+ T cells.
- Tsing-Lee Tang-Huau
- , Paul Gueguen
- & Elodie Segura
-
Article
| Open AccessMT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders. Here, the authors report that MT4-MMP-deficiency increases the recruitment of patrolling monocytes to early atherosclerotic lesions, which accelerates atherosclerosis.
- Cristina Clemente
- , Cristina Rius
- & Alicia G. Arroyo
-
Article
| Open AccessPeritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
Tissue-resident marcophages have both generic and tissue-specific functions, but how the latter functions are imbued is still unclear. Here the authors show that peritoneal macrophages express a specialised genetic programme to utilise the locally enriched glutamate for a metabolic setting that facilitates protective in situ immunity.
- Luke C. Davies
- , Christopher M. Rice
- & Daniel W. McVicar
-
Article
| Open AccessVSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
Macrophage differentiation and inflammatory function are controlled by cell metabolism. Here, the authors use a viral hepatitis model and a high-fat diet model of insulin resistance to show how VSIG4 inhibits inflammatory macrophage activation by modulating mitochondrial pyruvate metabolism.
- Jialin Li
- , Bo Diao
- & Yuzhang Wu