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| Open AccessA stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential
The ongoing emergence of highly pathogenic viruses that evade immune-based therapies or lack interventions mandates new approaches, especially for on-demand prophylaxis. Here the authors provide a stapled lipopeptide platform for the rapid development of viral fusion inhibitors to combat outbreaks.
- Gregory H. Bird
- , J. J. Patten
- & Loren D. Walensky
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Article
| Open AccessMachine learning-driven multifunctional peptide engineering for sustained ocular drug delivery
Sustained drug delivery is critical for patient adherence to chronic disease treatments. Here the authors apply machine learning to engineer multifunctional peptides with high melanin binding, high cell-penetration, and low cytotoxicity, enhancing the duration and efficacy of peptide-drug conjugates for sustained ocular delivery.
- Henry T. Hsueh
- , Renee Ti Chou
- & Laura M. Ensign
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Article
| Open AccessMultifunctional synthetic nano-chaperone for peptide folding and intracellular delivery
Molecular chaperones play an important part in protein folding and delivery in nature. Here, the authors report on the creation of a synthetic chaperone to control the folding of therapeutic peptides from random coil to alpha helix and demonstrate enhanced therapeutic potential in an in vivo tumour model.
- Il-Soo Park
- , Seongchan Kim
- & Dal-Hee Min
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Article
| Open AccessA Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically. Here, the authors develop a Klotho-derived peptide, and show that it recapitulates the anti-fibrotic action of Klotho and prevents kidney fibrosis in mice by targeting TGF-β signalling.
- Qian Yuan
- , Qian Ren
- & Youhua Liu
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Article
| Open AccessA bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging
Fluorescence probes for detecting tumours during surgery can suffer from poor accumulation and short imaging windows. Here, the author develop fluorescence probes with multiple motifs that permit enhanced circulation times, tumour targeting and use the probes to image pancreatic cancer in mice
- Han Ren
- , Xiang-Zhong Zeng
- & Li-Li Li
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Article
| Open AccessControlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
The clinical potential of peptide therapeutic agents can only be fully realised once their physicochemical and pharmacokinetic properties are precisely controlled. Here the authors show a reversible peptide self-assembly strategy to control and prolong the bioactivity of a native peptide hormone in vivo.
- Myriam M. Ouberai
- , Ana L. Gomes Dos Santos
- & Mark E. Welland
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Article
| Open AccessAcylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
A major challenge for the application of peptide therapeutics is their short half-lifein vivo. Here, the authors design peptide-fatty acid chimeras bearing an engineered linker that promotes albumin binding and allows longer circulation times of therapeutic peptides in animal models.
- Alessandro Zorzi
- , Simon J. Middendorp
- & Christian Heinis
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Article
| Open AccessBlood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to identify cell-penetrating peptides that can cross the BBB.
- Choi-Fong Cho
- , Justin M. Wolfe
- & Sean E. Lawler
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Article
| Open AccessHigh-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry
Assessing nanomaterials at the single cell level has proven to be complicated due to the limitations of existing techniques. Here, the authors utilised single-cell mass cytometry by time-of-flight as a label-free technique to analyse nanoparticle distribution within cells.
- Yu-Sang Sabrina Yang
- , Prabhani U. Atukorale
- & Darrell J. Irvine