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Article
| Open Access
An optogenetic approach for regulating human parathyroid hormone secretion
Parathyroid hormone (PTH) plays a role in maintaining calcium and phosphorus homeostasis, and in secondary hyperparathyroidism excess PTH secretion contributes to bone loss. Here the authors report an optogenetic approach to inhibit PTH secretion in human hyperplastic parathyroid cells, and prevented hyperplastic parathyroid tissue-induced bone loss in mice.
- Yunhui Liu
- , Lu Zhang
- & Fan Yang
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Article
| Open Access
Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
Elevated inorganic phosphate levels promote excessive parathyroid hormone secretion, which contributes to the aetiology of secondary hyperparathyroidism. Here, the authors show that phosphate directly inhibits the calcium-sensing receptor, the main regulator of parathyroid hormone secretion.
- Patricia P. Centeno
- , Amanda Herberger
- & Donald T. Ward
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Article
| Open Access
Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism
Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demonstrate its efficacy in rats.
- Tatsuya Tamura
- , Hiroshi Noda
- & Yoshiki Kawabe
Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids