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Osteopontin is an acidic phosphoprotein produced by osteoblasts and other cell types. Osteopontin is an extracellular protein that has a cell-adhesion sequence (RGD) that mediates its interaction with integrins and extracellular matrix components. It has functions in biomineralization of bone, chemotaxis, apoptosis and cell activation in immunity.
Intracellular and secreted isoforms of osteopontin differentially regulate myeloid progenitors and differentiated lymphoid cells, respectively, through pro- and anti-apoptotic effects.
