Organic chemistry

Organic chemistry is the study of the synthesis, structure, reactivity and properties of the diverse group of chemical compounds primarily constructed of carbon. All life on earth is carbon-based, thus organic chemistry is also the basis of biochemistry. The ability to form compounds containing long chains of carbon atoms is the basis of polymer chemistry.

Latest Research and Reviews

News and Comment

  • News and Views |

    The direct formation of C–N bonds onto arenes provides a simple route to synthesize a variety of important products. Now, formation of a highly polarized, aminium radical cation enables direct C–H amination, allowing the coupling of an exceptionally broad range of alkyl amines and arenes.

    • David Nagib
    Nature Chemistry 11, 396-398
  • Research Highlights |

    Seven-membered rings are rare motifs in fullerene derivatives. However, these motifs can be stabilized by adjacent five-membered rings and feature in a hydrofullerene isolated from combustion soot.

    • David Schilter
  • News and Views |

    Natural products often provide lead scaffolds for the development of therapeutics, but complexity of their synthesis can limit the discovery of improved analogues. Pharmacophore-directed retrosynthesis aims to accelerate the building of a structure–activity relationship profile of a natural product, aiming to identifying a simplified lead.

    • Jason R. Hudlicky
    •  & Gary A. Sulikowski
    Nature Chemistry 11, 297-298
  • Research Highlights |

    A biomimetic total synthesis of (–)-oxycodone relies on an electrochemically mediated coupling of two oxygenated aryl rings for a key bond formation.

    • Stephen G. Davey