Optical imaging articles from across Nature Portfolio

Optical imaging includes a variety of imaging techniques that rely on illumination light in the ultraviolet, visible and infrared regions of the electromagnetic spectrum. The term typically excludes classical microscopy techniques in favour of larger scale imaging methods that rely on the detection of ballistic or diffusive photons, or the photoacoustic effect.

Latest Research and Reviews

Research
05 June 2023 | Open Access

Parallel interrogation of the chalcogenide-based micro-ring sensor array for photoacoustic tomography

The authors report a highly sensitive chalcogenide-based micro-ring sensor array for photoacoustic tomography and develops a compatible parallel interrogation means by synthesizing a digital optical frequency comb. Imaging is demonstrated on fast-moving objects, leaf veins, and live zebrafish.
- Jingshun Pan
- , Qiang Li
- & Zhaohui Li
Nature Communications 14, 3250
Research
31 May 2023 | Open Access

Label-free nanoscale mapping of intracellular organelle chemistry

Intracellular structures are mapped in human multiple myeloma cells through label-free chemical mapping at nanoscale resolution, yielding sub-diffraction images of the ER, mitochondria and nucleoli.
- George E. Greaves
- , Darya Kiryushko
- & Chris C. Phillips
Communications Biology 6, 583
Research
29 May 2023 | Open Access

High-resolution structural and functional retinal imaging in the awake behaving mouse

A high-resolution imaging apparatus that allows functional retinal imaging in awake and free moving mice was developed, allowing the study of the effect of anaesthesia on eye motion, blood flow and retinal thickness.
- Guanping Feng
- , Aby Joseph
- & Jesse Schallek
Communications Biology 6, 572
Reviews
25 May 2023 | Open Access

Viewing life without labels under optical microscopes

This Perspective looks at the choice of label-free optical microscopes available and discusses applications as well as scope for further improvement of labelfree imaging.
- Biswajoy Ghosh
- & Krishna Agarwal
Communications Biology 6, 559
Research
24 May 2023 | Open Access

Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice

Brain vascular impairment may occur early in diseases such as Alzheimer’s disease. Here the authors longitudinally study brain vascular dynamics in mice using advanced optical coherence tomography and deep learning algorithms, which enables tracking of slow vascular decline in aging and models of disease.
- Konrad W. Walek
- , Sabina Stefan
- & Jonghwan Lee
Nature Communications 14, 2982
Research
13 May 2023 | Open Access

A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma

Neodymium (Nd)-doped nanoparticles have been described for imaging-guided photothermal therapy. Here the authors design a Nd-Yb co-doped nanomaterial as nearinfrared long-lifetime imaging-guided waterheating probe, showing photothermal ablation in a glioblastoma pre-clinical mode
- Dongkyu Kang
- , Hyung Shik Kim
- & Joonseok Lee
Nature Communications 14, 2755

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News and Comment

Research Highlights | 11 May 2023

Imaging behavior with a camera array
- Nina Vogt
Nature Methods 20, 632
News & Views | 30 March 2023

Line-scanning speeds up Brillouin microscopy

Two new Brillouin microscopes leverage line-scanning to overcome previous limitations of the technique, enabling fast imaging, with low phototoxicity, of mechanical properties in living embryos of model organisms and tumor spheroids.
- Nargess Khalilgharibi
- , Giulia Paci
- & Yanlan Mao
Nature Methods 20, 643-644
Research Highlights | 03 November 2022

A diamond microscope
- Nina Vogt
Nature Methods 19, 1339
Comments & Opinion | 11 January 2022

Imaging without the labels

Advances in label-free microscopy are expanding experimental observations, from biophysics to cell biology and beyond.
- Rita Strack
Nature Methods 19, 30
Editorial | 03 December 2021

Minding microscopy metadata

Guidelines for improving reporting and reproduciblity in microscopy take center stage in this month’s Focus issue.

Nature Methods 18, 1411
Comments & Opinion | 21 May 2021

REMBI: Recommended Metadata for Biological Images—enabling reuse of microscopy data in biology

Bioimaging data have significant potential for reuse, but unlocking this potential requires systematic archiving of data and metadata in public databases. We propose draft metadata guidelines to begin addressing the needs of diverse communities within light and electron microscopy. We hope this publication and the proposed Recommended Metadata for Biological Images (REMBI) will stimulate discussions about their implementation and future extension.
- Ugis Sarkans
- , Wah Chiu
- & Alvis Brazma
Nature Methods 18, 1418-1422

All News & Comment

Optical imaging articles from across Nature Portfolio

Latest Research and Reviews

Parallel interrogation of the chalcogenide-based micro-ring sensor array for photoacoustic tomography

Label-free nanoscale mapping of intracellular organelle chemistry

High-resolution structural and functional retinal imaging in the awake behaving mouse

Viewing life without labels under optical microscopes

Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice

A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma

News and Comment

Imaging behavior with a camera array

Line-scanning speeds up Brillouin microscopy

A diamond microscope

Imaging without the labels

Minding microscopy metadata

REMBI: Recommended Metadata for Biological Images—enabling reuse of microscopy data in biology

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