We developed a high-content profiling method named vibrational painting (VIBRANT) for single-cell drug response measurements, combining vibrational imaging, multiplexed vibrational probes and machine learning. VIBRANT showed high performance in predicting drug mechanisms of action, discovering novel compounds and assessing drug combinations, demonstrating great promise for phenotypic drug discovery.
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This is a summary of: Liu, X., Shi, L., Zhao, Z., Shu, J. & Min, W. VIBRANT: spectral profiling for single-cell drug responses. Nat. Methods https://doi.org/10.1038/s41592-024-02185-x (2024).
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VIBRANT: a phenotyping method for drug discovery using vibrational spectroscopy. Nat Methods 21, 389–390 (2024). https://doi.org/10.1038/s41592-024-02186-w
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DOI: https://doi.org/10.1038/s41592-024-02186-w
