Oesophagitis articles within Nature Communications

Featured

• Article
  23 November 2021 | Open Access

  Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis

  Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease with a complex underlying genetic etiology. Here, the authors identify a series of rare variants in DSP and PPL in multiplex families with EoE and uncover a pathogenic role for desmosomal dysfunction in EoE.

  • Tetsuo Shoda
  • , Kenneth M. Kaufman
  •  & Marc E. Rothenberg

• Article | 19 November 2014

  GWAS identifies four novel eosinophilic esophagitis loci

  Eosinophilic oesophagitis (EoE) is an allergic, inflammatory disorder of the oesophagus. Here the authors carry out a genome-wide association study in over 5,000 individuals and identify four genetic loci that affect the onset of EoE.

  • Patrick M. A. Sleiman
  • , Mei-Lun Wang
  •  & Hakon Hakonarson