Featured
-
-
Research Highlight |
Salt substitution reduces the rate of cardiovascular events and death
In the SSaSS trial, substituting regular table salt (100% sodium chloride) with an alternative containing 25% potassium chloride reduced the rate of stroke, major cardiovascular events and all-cause death.
- Gregory B. Lim
-
Research Highlight |
Restoration of NAD+ levels as a therapy for HFpEF
A new study demonstrates a deficiency of NAD+ in patients with heart failure with preserved ejection fraction and indicates that restoration of NAD+ levels with nicotinamide supplementation might have therapeutic value to treat diastolic dysfunction in these patients.
- Andrew Robson
-
-
-
Review Article |
Dietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes
Dietary fats comprise heterogeneous molecules with diverse structures and complex health effects. This Review discusses the effects of different dietary fats on cell processes and cardiometabolic disease risk factors and clinical events, highlighting areas of controversy and future research directions to improve the prevention and management of cardiometabolic diseases through optimization of dietary fat intake.
- Jason H. Y. Wu
- , Renata Micha
- & Dariush Mozaffarian
-
Year in Review |
Nutrient supplementation no substitute for healthy diets
The VITAL trial showed that neither vitamin D nor fish oil supplementation significantly reduced the incidence of cardiovascular disease (CVD). Conversely, current evidence supports the benefits of multiple dietary patterns, especially the Mediterranean diet, in primary prevention of CVD. Health effects of low-carbohydrate diets depend on the food sources of macronutrients.
- Frank B. Hu
-
-
-
Review Article |
Interventions to promote cardiometabolic health and slow cardiovascular ageing
Cardiovascular ageing and the atherosclerotic process begin very early in life and progress over decades of exposure to suboptimal metabolic and hormonal risk factors. In this Review, Fontana discusses how various approaches, including calorie restriction, intermittent fasting, regular physical activity, and mindfulness-based stress-reduction exercises, can slow the effects of cardiovascular ageing and promote cardiometabolic health.
- Luigi Fontana
-
Review Article |
Beyond gut feelings: how the gut microbiota regulates blood pressure
A growing body of evidence supports the role of the gut microbiota in regulating blood pressure. In their Review, Marques and co-workers describe how the gut microbiota and its metabolites act on downstream cellular targets to influence the pathogenesis of hypertension. Novel strategies to modify the gut microbiota might present a new therapeutic avenue to improve health and prevent disease.
- Francine Z. Marques
- , Charles R. Mackay
- & David M. Kaye
-
-
Review Article |
Nutraceutical therapies for atherosclerosis
Nutraceuticals are natural compounds that are beneficial for the prevention or treatment of disease. In their Review, Moss and Ramji summarize the preclinical and clinical studies to evaluate the efficacy of various nutraceuticals, such as polyunsaturated fatty acids, flavanols, and vitamins C and E, for the prevention of atherosclerosis.
- Joe W. E. Moss
- & Dipak P. Ramji
-
Review Article |
Vitamin D and cardiovascular disease prevention
This Review summarizes the existing knowledge on the effects of vitamin D on cardiovascular diseases and the associated risk factors. Pilz and colleagues provide an update on clinical studies on vitamin D and cardiovascular risk, discuss ongoing vitamin D research, and consider the management of vitamin D deficiency from the perspective of cardiovascular health.
- Stefan Pilz
- , Nicolas Verheyen
- & Winfried März
-
-
-
Research Highlight |
Mechanistic insights into the cardiovascular benefits of a Mediterranean diet
- Gregory B. Lim
-
Research Highlight |
Vitamin D supplementation lacks benefit in systolic hypertension
- Gregory B. Lim
-
-
-
-
-
Review Article |
The role of nutrition and body composition in peripheral arterial disease
Preliminary evidence suggests that therapies focused on nutrition and weight loss might reduce the incidence of peripheral arterial disease (PAD), as well as ameliorate functional impairment and improve ischemic outcomes in patients with PAD. The authors summarize the available data on the effects of nutrition and anthropometric factors on PAD incidence and risk, and discuss potential nutritional strategies for the prevention and treatment of the disease.
- Diana P. Brostow
- , Alan T. Hirsch
- & Mindy S. Kurzer
-
Research Highlight |
Study sheds light on importance of vitamin D in patients with HF
- Gregory B. Lim
-
Review Article |
Dietary factors associated with hypertension
Several dietary components contribute to the development and progression of hypertension. Dong Zhao and colleagues review the available evidence for the association of various dietary factors with blood pressure and hypertension, the dietary recommendations of national and international guidelines on hypertension prevention and management, and the outcomes of diet-based public policy plans on hypertension control.
- Dong Zhao
- , Yue Qi
- & Jing Liu
-
Research Highlight |
Supplements not cardioprotective for patients with a history of CVD
- Rowan Higgs
-
Research Highlight |
Low-dose omega-3 supplementation—no beneficial effect in patients with prior MI
- Alexandra King
-
-
Research Highlight |
Omega-3 supplements do not prevent atrial fibrillation after CABG surgery
- Alexandra King
-
Metabolic product of excess niacin is linked to increased risk of cardiovascular events
Dietary supplements undergo VITAL test
No benefit of n-3 fatty acid supplements in diabetes
Cardioprotective benefits of dietary spermidine
Biological ageing—a potentially modifiable risk factor for CAD?