Featured
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Article |
Gasdermin E suppresses tumour growth by activating anti-tumour immunity
The gasdermin E protein is shown to act as a tumour suppressor: it is cleaved by caspase 3 and granzyme B and leads to pyroptosis of cancer cells, provoking an immune response to the tumour.
- Zhibin Zhang
- , Ying Zhang
- & Judy Lieberman
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Letter |
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell activation and that its blockade may be of use in cancer therapy.
- Martina Molgora
- , Eduardo Bonavita
- & Alberto Mantovani
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Research Highlights |
Controlling natural killers
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Outlook |
Asthma: Breathing new life into research
Asthma was once thought to be a uniform disease triggered by one type of immune cell. Researchers are now revealing the complexity of the condition and hope to hasten new drugs for forms unresponsive to steroids.
- Amy Maxmen
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Letter |
Natural killer cells act as rheostats modulating antiviral T cells
Natural killer cells can act as rheostats, or ‘master regulators’, controlling antiviral T-cell responses.
- Stephen N. Waggoner
- , Markus Cornberg
- & Raymond M. Welsh
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Letter |
HIV-1 adaptation to NK-cell-mediated immune pressure
- Galit Alter
- , David Heckerman
- & Marcus Altfeld
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Research Highlights |
Immunology: Killer cells help
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells