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| Open AccessA clinically applicable deep-learning model for detecting intracranial aneurysm in computed tomography angiography images
Interpretation of Computed Tomography Angiography for intracranial aneurysm diagnosis can be time-consuming and challenging. Here, the authors present a deep-learning-based framework achieving improved performance compared to that of radiologists and expert neurosurgeons.
- Zhao Shi
- , Chongchang Miao
- & Long Jiang Zhang
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Article
| Open AccessCerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia
Diagnosis of vascular dementia is hampered by the lack of biochemical markers for this disease. Here, the authors show that vascular dementia is associated with increased lipocalin-2 in cerebrospinal fluid, compared to controls and patients with other forms of dementia.
- Franc Llorens
- , Peter Hermann
- & Inga Zerr
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Article
| Open AccessPrecapillary sphincters maintain perfusion in the cerebral cortex
Precapillary sphincters are mural cells encircling an indentation of blood vessels where capillaries branch off from penetrating arterioles (PAs), but their existence and role in the brain is not fully understood. Here authors describe these structures at PAs in the cortex and show that they constrict during cortical spreading depolarization in mice.
- Søren Grubb
- , Changsi Cai
- & Martin Lauritzen
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The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction
Amyloid-beta has been shown to induce cerebrovascular defects that may contribute to the progression of Alzheimer's dementia. Park et al.show that amyloid-beta impairs vascular function by upregulating oxidative stress-induced DNA damage, resulting in opening of TRPM2 channels.
- L. Park
- , G. Wang
- & C. Iadecola
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PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
PI 3-kinase is a major regulator of inflammatory responses. In this study, the authors show that inhibition of the delta isoform of PI 3-kinase attenuates the release of tumour necrosis factor from microglia as well as the signs and symptoms associated with cerebral stroke in an in vivomouse model.
- Pei Ching Low
- , Silvia Manzanero
- & Frédéric A. Meunier