Neurological disorders articles within Nature Reviews Clinical Oncology

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  • Evidence-based Guidelines
    | Open Access

    Herein, the European Association of Neuro-Oncology (EANO) provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. These evidence-based guidelines incorporate major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System as well as on evidence from recent large clinical trials.

    • Michael Weller
    • , Martin van den Bent
    •  & Wolfgang Wick

  • News & Views |

    Developing novel technologies to discriminate malignant tissue from nonmalignant structures and thereby facilitate safe, complete tumour resection is a major priority for advancing oncological neurosurgery. Herein, we discuss a recently reported innovation involving stimulated Raman spectroscopy of intraoperative tissue samples and data interpretation with artificial intelligence, as well as the implications of this approach for neurosurgical oncology.

    • Michael L. Martini
    •  & Eric K. Oermann

  • Comment |

    Experimental research on cancer-associated cachexia is advancing at an accelerated pace while knowledge of the complex underlying biology of cachexia in humans lags behind. An unmet need exists to accelerate the identification of causal mechanisms in patients with cancer and to determine the parallels between experimental systems and distinct isotypes of human cachexia.

    • Vickie E. Baracos

  • Review Article |

    Neurotoxicity caused by treatment is widely recognized in patients with cancer. This Review addresses the main neurotoxicities of cancer treatment with a focus on the newer therapeutics. Recognition of these patterns of toxicity is important because drug discontinuation or dose adjustment might prevent further neurological injury. Familiarity with the neurological syndromes associated with cancer treatments enables clinicians to use the appropriate treatment for the underlying malignancy while minimizing the risk of neurological damage, which might preserve patient quality of life.

    • Jacqueline B. Stone
    •  & Lisa M. DeAngelis

  • Review Article |

    Radiotherapy has an important role in the treatment of metastatic epidural spinal cord compression; when used alone, it is important to select the most suitable radiotherapy regimen. In this Review, Rades and Abrahm report that longer-course radiotherapy is associated with better local control than short-course radiotherapy. However, short-course radiotherapy is more suitable than longer-course treatment in patients with a poor prognosis.

    • Dirk Rades
    •  & Janet L. Abrahm

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