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Bridging the gap: are animal models consistent with clinical cancer cachexia?

Experimental research on cancer-associated cachexia is advancing at an accelerated pace while knowledge of the complex underlying biology of cachexia in humans lags behind. An unmet need exists to accelerate the identification of causal mechanisms in patients with cancer and to determine the parallels between experimental systems and distinct isotypes of human cachexia.

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Acknowledgements

VEB receives grant support from the Canadian Institutes of Health Research and the Alberta Cancer Foundation.

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Correspondence to Vickie E. Baracos.

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Baracos, V. Bridging the gap: are animal models consistent with clinical cancer cachexia?. Nat Rev Clin Oncol 15, 197–198 (2018). https://doi.org/10.1038/nrclinonc.2018.14

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