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| Open AccessEarly aggregation preceding the nucleation of insulin amyloid fibrils as monitored by small angle X-ray scattering
- Eri Chatani
- , Rintaro Inoue
- & Toshiji Kanaya
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| Open AccessProteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer’s disease brain tissue
- Eleanor S Drummond
- , Shruti Nayak
- & Thomas Wisniewski
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| Open AccessConformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect
- Chia-Sui Sun
- , Chi-Chang Lee
- & Joseph Jen-Tse Huang
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| Open AccessBaclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion
- Li Liu
- , Chang-jun Li
- & Lian-jun Guo
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| Open AccessReporter pathway analysis from transcriptome data: Metabolite-centric versus Reaction-centric approach
- Tunahan Çakır
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| Open AccessLeveraging existing data sets to generate new insights into Alzheimer’s disease biology in specific patient subsets
- Kevin D. Fowler
- , Jason M. Funt
- & Fadi Towfic
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| Open AccessConjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease
- Galina F. Makhaeva
- , Sofya V. Lushchekina
- & Sergey O. Bachurin
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| Open AccessComprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers
- Joshua T. Dearborn
- , Steven K. Harmon
- & David F. Wozniak
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| Open AccessIntegrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease
- Xinzhong Li
- , Jintao Long
- & James Scott
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| Open AccessScopolamine effects on functional brain connectivity: a pharmacological model of Alzheimer’s disease
- R. Bajo
- , S. Pusil
- & E. Pekkonen
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Article
| Open AccessSpinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches
- Monica Nizzardo
- , Chiara Simone
- & Stefania Corti
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| Open AccessMicroglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
- Wenjie Luo
- , Wencheng Liu
- & Steven M. Paul
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| Open AccessPharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
- Mario de la Mata
- , David Cotán
- & José A. Sánchez-Alcázar
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| Open AccessHippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model
- Jin-Seok Lee
- , Hyeong-Geug Kim
- & Chang-Gue Son
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| Open AccessHighly efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neurons
- Marie Frickenhaus
- , Marina Wagner
- & Erik Storkebaum
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| Open AccessInfluence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease
- Kai Lun Chang
- , Hai Ning Pee
- & Paul C. Ho
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Article
| Open AccessAurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis
- Jie Tian
- , Chuan Tian
- & Jing Li
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| Open AccessTruncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease
- Nana Jin
- , Xiaomin Yin
- & Fei Liu
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| Open AccessLevodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats
- Cheng-long Xie
- , Wen-Wen Wang
- & Zhen-Guo Liu
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| Open AccessTaurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease
- Hye Yun Kim
- , Hyunjin V. Kim
- & YoungSoo Kim
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Article
| Open AccessCorrelations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model
- Soo Min Cho
- , Hyunjin Vincent Kim
- & YoungSoo Kim
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| Open AccessQuantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry
- John F. Kellie
- , Richard E. Higgs
- & Michael D. Knierman
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| Open AccessTR-FRET Assays of Huntingtin Protein Fragments Reveal Temperature and PolyQ Length-Dependent Conformational Changes
- Xiaotian Cui
- , Qingnan Liang
- & Boxun Lu
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| Open AccessUbiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins
- Deepak Chhangani
- , Arun Upadhyay
- & Amit Mishra
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| Open AccessThe c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
- Senthilkumar S. Karuppagounder
- , Saurav Brahmachari
- & Han Seok Ko
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| Open AccessApolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis
- Mengying Liu
- , Chen Bian
- & Feng Wen
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| Open AccessUltrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation
- Claire Tinker-Mill
- , Jennifer Mayes
- & Oleg V. Kolosov
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| Open AccessAge-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
- Zhipeng Xu
- , Yuanlin Dong
- & Zhongcong Xie
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| Open AccessER stress upregulated PGE2/IFNγ-induced IL-6 expression and down-regulated iNOS expression in glial cells
- Toru Hosoi
- , Miya Honda
- & Koichiro Ozawa
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Article
| Open AccessBiomarker-guided translation of brain imaging into disease pathway models
- Erfan Younesi
- & Martin Hofmann-Apitius
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Article
| Open AccessOral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice
- Akio Matsumoto
- , Megumi Yamafuji
- & Haruaki Nakaya
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| Open AccessMechanism of amyloid β−protein dimerization determined using single−molecule AFM force spectroscopy
- Zhengjian Lv
- , Robin Roychaudhuri
- & Yuri L. Lyubchenko
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Article
| Open AccessAutologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys
- Zhenhua Ren
- , Jiayin Wang
- & Y. Alex Zhang
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| Open AccessFUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
- Yusuke Fujioka
- , Shinsuke Ishigaki
- & Gen Sobue
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| Open AccessS-nitrosylation regulates mitochondrial quality control via activation of parkin
- Kentaro Ozawa
- , Akira T. Komatsubara
- & Masanori Yoshizumi
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| Open AccessLocation- and sex-specific differences in weight and motor coordination in two commonly used mouse strains
- Attila D. Kovács
- & David A. Pearce
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| Open AccessA TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain
- Cristina Nativi
- , Roberta Gualdani
- & Stefano Roelens
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| Open AccessMahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity
- Deepak Chhangani
- & Amit Mishra
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| Open AccessMicrofluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation
- Hansang Cho
- , Tadafumi Hashimoto
- & Daniel Irimia
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| Open AccessGliotoxicity of the cyanotoxin, β-methyl-amino-L-alanine (BMAA)
- Alexander S. Chiu
- , Michelle M. Gehringer
- & Brett A. Neilan
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| Open AccessCessation of Neoangiogenesis in Alzheimer's Disease Follows Amyloid-beta Immunization
- Kaan E. Biron
- , Dara L. Dickstein
- & Wilfred A. Jefferies
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| Open AccessDiscovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease
- Tiziana Alberio
- , Agnese C. Pippione
- & Mauro Fasano
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| Open AccessCellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species
- Steffen J. Sahl
- , Lucien E. Weiss
- & W. E. Moerner