Neuro–vascular interactions articles within Nature

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• Article
  28 February 2024 | Open Access

  Multisensory gamma stimulation promotes glymphatic clearance of amyloid

  Audio and visual stimulation at 40 Hz promote cerebrospinal and interstitial fluid flux in mouse brain and result in amyloid clearance via the glymphatic system in a mouse model of Alzheimer’s disease.

  • Mitchell H. Murdock
  • , Cheng-Yi Yang
  •  & Li-Huei Tsai

• Article | 30 May 2022

  Brain motor and fear circuits regulate leukocytes during acute stress

  Distinct brain regions differentially and rapidly tailor the leukocyte landscape during psychological stress, calibrating the ability of the immune system to respond to physical threats.

  • Wolfram C. Poller
  • , Jeffrey Downey
  •  & Filip K. Swirski

• Article | 12 August 2020

  Interpericyte tunnelling nanotubes regulate neurovascular coupling

  Retinal pericytes connect via interpericyte tunnelling nanotubes into functional syncytia that regulate microcirculatory blood flow to help to match local blood flow with neuronal activity.

  • Luis Alarcon-Martinez
  • , Deborah Villafranca-Baughman
  •  & Adriana Di Polo

• Article | 01 July 2020

  Physiological blood–brain transport is impaired with age by a shift in transcytosis

  Tagging and tracking the blood plasma proteome as a discovery tool reveals widespread endogenous transport of proteins into the healthy brain and the pharmacologically modifiable mechanisms by which the brain endothelium regulates this process with age.

  • Andrew C. Yang
  • , Marc Y. Stevens
  •  & Tony Wyss-Coray

• Article | 19 February 2020

  Caveolae in CNS arterioles mediate neurovascular coupling

  Caveolae in arteriolar endothelial cells—but not those in neighbouring smooth muscle cells—have a key role in neurovascular coupling, an essential function for meeting acute brain energy demand.

  • Brian W. Chow
  • , Vicente Nuñez
  •  & Chenghua Gu

• Article | 23 October 2019

  Dietary salt promotes cognitive impairment through tau phosphorylation

  A high-salt diet in mice induces cognitive impairment through a signalling cascade that culminates in increased phosphorylation of tau.

  • Giuseppe Faraco
  • , Karin Hochrainer
  •  & Costantino Iadecola

• Article | 24 July 2019

  Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

  Clearance of macromolecules from the cerebrospinal fluid in mice takes place via meningeal lymphatic vessels at the base of the skull; both drainage and the integrity of these vessels deteriorate with age.

  • Ji Hoon Ahn
  • , Hyunsoo Cho
  •  & Gou Young Koh

• Letter | 25 May 2016

  Neural correlates of single-vessel haemodynamic responses in vivo

  Functional imaging techniques use changes in blood flow to infer neural activity, but how strongly the two are correlated is a subject of debate; here, vascular and neural responses to a range of visual stimuli are imaged in cat and rat primary visual cortex, revealing that vascular signals are partially decoupled from local neural signals.

  • Philip O’Herron
  • , Pratik Y. Chhatbar
  •  & Prakash Kara

• Letter | 04 December 2013

  Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period

  In mice, chronic stimulation by repetitive sounds, whisker deflection, motor activity or seizures during a postnatal developmental critical period, leads to permanent reductions in brain microvascular density, an effect that impairs oxygen delivery to neurons but can be prevented by blocking nitric oxide signalling.

  • Christina Whiteus
  • , Catarina Freitas
  •  & Jaime Grutzendler