Neural patterning articles within Nature Communications

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  • Article
    | Open Access

    Neural mechanisms underlying brain-wide synchronization are not fully understood. Here authors show that traveling waves are prevalent in both excitatory and inhibitory neural populations, more pronounced in glutamatergic neurons, vary across developmental stages, and are associated with functional connections and gene expression.

    • Liang Shi
    • , Xiaoxi Fu
    •  & Pengcheng Li

  • Article
    | Open Access

    Retinoic acid signaling is involved in patterning the embryonic antero-posterior axis, and also regulates hindbrain segmentation in jawed vertebrates. Here they show that retinoic acid signaling plays important roles in hindbrain segmentation in a jawless vertebrate, the lamprey, thus indicating this feature of hindbrain development is conserved in all vertebrates.

    • Alice M. H. Bedois
    • , Hugo J. Parker
    •  & Robb Krumlauf

  • Article
    | Open Access

    Proteomic data covering fetal and neonatal primate brain development in the primate brain is needed to understand development and changes in functional gene products. Here, the authors show the dynamic proteomic changes of the cynomolgus macaque brain during the development from early fetal to neonatal stages by constructing a spatiotemporal proteomic atlas.

    • Jingkuan Wei
    • , Shaoxing Dai
    •  & Wei Si

  • Article
    | Open Access

    Brain asymmetry is widespread across species, but its function remains poorly understood. Here, the authors show that the Netrin axon guidance pathway is involved in building an asymmetric neural circuit important for long-term memory in Drosophila.

    • F. Lapraz
    • , C. Boutres
    •  & S. Noselli

  • Article
    | Open Access

    The cellular and molecular mechanisms regulating hypothalamic patterning and differentiation are unclear. Here, the authors profiled the transcriptome of the developing hypothalamus at single cell level, providing a resource to hypothalamic development in health and disease.

    • Dong Won Kim
    • , Parris Whitney Washington
    •  & Seth Blackshaw

  • Article
    | Open Access

    Sex differences in placental O-linked N-acetylglucosamine transferase (OGT) activity mediate the effects of prenatal stress on neurodevelopmental programming. Here authors provide evidence that OGT confers variation in vulnerability to prenatal insults by establishing sex-specific trophoblast gene expression via regulation of H3K27me3.

    • Bridget M. Nugent
    • , Carly M. O’Donnell
    •  & Tracy L. Bale

  • Article
    | Open Access

    Development of neural circuits for face recognition is not well studied in primates. Here the authors longitudinally track responses to faces in monkeys from about a month of age to two years and demonstrate that face-selective responses emerge in inferotemporal cortex early and gradually stabilize over time.

    • Margaret S. Livingstone
    • , Justin L. Vincent
    •  & Tristram Savage

  • Article
    | Open Access

    The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titrating VEGF via the expression of its trapping receptor sFlt1.

    • Patricia Himmels
    • , Isidora Paredes
    •  & Carmen Ruiz de Almodóvar

  • Article
    | Open Access

    The holistic retrieval of complex event memories is thought to be the hallmark of episodic memory. Here, the authors provide behavioural and neuroimaging evidence that the hippocampus binds together the elements forming an event to allow holistic episodic recollection via pattern completion of all elements.

    • Aidan J. Horner
    • , James A. Bisby
    •  & Neil Burgess

  • Article
    | Open Access

    Aggregate signals in cortex are spatiotemporally organized as propagating waves across the cortical surface. Here the authors demonstrate that neurons in primary motor cortex of monkeys spatially coordinate their spiking activity in a manner that closely matches wave propagation.

    • Kazutaka Takahashi
    • , Sanggyun Kim
    •  & Nicholas G. Hatsopoulos

  • Article
    | Open Access

    Gradients of the secreted morphogen Sonic Hedgehog (Shh) pattern the neural tube in vertebrates. Cohen et al.quantify Shh signalling in developing mice, and by constructing a computational model of the process, identify mechanisms by which the dynamics of Shh signalling are regulated.

    • Michael Cohen
    • , Anna Kicheva
    •  & James Briscoe

  • Article
    | Open Access

    The spatiotemporal pattern of synaptic inputs is critical for synaptic integration and plasticity in neurons but whether these inputs are structured or random is not clear. Here the authors use in vivocalcium imaging to monitor the presynaptic activity of cerebellar parallel fibre axons and find clustered patterns of axonal activity during sensory processing.

    • Christian D. Wilms
    •  & Michael Häusser

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