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| Open AccessA direct interareal feedback-to-feedforward circuit in primate visual cortex
In the cerebral cortex, information is processed by multiple hierarchically organized areas, reciprocally connected via feedforward and feedback circuits. Here the authors show that in primate visual cortex, feedforward projection neurons receive monosynaptic feedback contacts selectively from the area to which they project.
- Caitlin Siu
- , Justin Balsor
- & Alessandra Angelucci
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Article
| Open AccessHeritability and interindividual variability of regional structure-function coupling
The relationship between the human structural and functional connectome is still not well established. Here the authors show the interindividual variability that exists in regional coupling of structural and functional connectivity across the brain, and that this is heritable.
- Zijin Gu
- , Keith Wakefield Jamison
- & Amy Kuceyeski
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| Open AccessLocomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord
The mechanisms stimulating adult neurogenesis are unclear. Here, the authors show the contribution of cholinergic and GABAergic signalling within the locomotor network to spinal cord neurogenesis during homeostasis and regeneration, showing neurogenesis depends on circuit activity in the adult zebrafish.
- Weipang Chang
- , Andrea Pedroni
- & Konstantinos Ampatzis
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| Open AccessPlace fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts
Hippocampal pyramidal cells encode an animal’s location by single action potentials and complex spike bursts. The authors show that Kcnq3-containing M-channels synergistically with GABAergic inputs coordinate complex spike bursts during theta oscillations, which is a key mechanism for spatial coding by single spikes.
- Xiaojie Gao
- , Franziska Bender
- & Alexey Ponomarenko
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Article
| Open AccessA genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
Engineering de novo synapse-like connections between neurons could enhance our understanding of neuronal circuits and how they generate behaviour. The authors present a two-component system that creates synthetic neuromodulatory connections to manipulate intracellular Ca2+ levels in in vivo neural circuits.
- Josh D. Hawk
- , Elias M. Wisdom
- & Daniel A. Colón-Ramos
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| Open AccessCell specific photoswitchable agonist for reversible control of endogenous dopamine receptors
In this study, the authors develop a photo-pharmacological strategy using a Membrane anchored Photoswitchable orthogonal remotely tethered agonist for the Dopamine receptor (MP-D) to selectively and reversibly modulate the D1R receptor subtype.
- Prashant Donthamsetti
- , Nils Winter
- & Ehud Isacoff
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Article
| Open AccessInhibitory gating of coincidence-dependent sensory binding in secondary auditory cortex
Sound processing requires binding of frequency components into a unified perceptual object. Here the authors investigate the neural correlates in the mouse secondary auditory cortex underlying multifrequency binding in response to harmonic sounds.
- Amber M. Kline
- , Destinee A. Aponte
- & Hiroyuki K. Kato
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| Open AccessReverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks
Microbial rhodopsins can be used to control action potentials, while animal opsins can be used to control intracellular signaling pathways. The authors identify Opn7b as constitutively active Gi/o coupled receptor that can be deactivated by light and used to modulate neuronal activity.
- Raziye Karapinar
- , Jan Claudius Schwitalla
- & Stefan Herlitze
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Article
| Open AccessAuditory input enhances somatosensory encoding and tactile goal-directed behavior
Multi-sensory input can lead to dendritic integration at the single neuron level. Here the authors show that combined auditory and somatosensory input increases distal dendritic and somatic activity in layer 2/3 pyramidal neurons of the primary somatosensory cortex and decreases response latency during somatosensory-based goal-directed behaviour.
- L. Godenzini
- , D. Alwis
- & L. M. Palmer
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Article
| Open AccessThe tectonigral pathway regulates appetitive locomotion in predatory hunting in mice
Goal-oriented movement is a fundamental animal behaviour. Here, the authors show that neurons in the superior colliculus project to the substantia nigra pars compacta, regulating dopaminergic signaling and specifically appetitive locomotion in mice.
- Meizhu Huang
- , Dapeng Li
- & Peng Cao
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Article
| Open AccessParallel processing of working memory and temporal information by distinct types of cortical projection neurons
Intratelencephalic and pyramidal tract neurons are two major types of cortical excitatory neurons that project to cortical and subcortical structures. The authors show that in the prefrontal cortex the two populations have different roles for the maintenance of working memory and for tracking the passage of time.
- Jung Won Bae
- , Huijeong Jeong
- & Min Whan Jung
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Article
| Open AccessNeurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1.
- Valentina Botero
- , Bethany A. Stanhope
- & Seth M. Tomchik
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Article
| Open AccessGenetic influences on hub connectivity of the human connectome
How genes sculpt the complex architecture of the human connectome remains unclear. Here, the authors show that genes preferentially influence the strength of connectivity between functionally valuable, metabolically costly connections between brain network hubs.
- Aurina Arnatkeviciute
- , Ben D. Fulcher
- & Alex Fornito
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| Open AccessRamp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
The neural mechanisms by which the brain initiates self-generated actions are unclear. The authors show, using population imaging and single-cell ablation, that ramp-to-threshold firing dynamics over multiple seconds is critical for the initiation of self-generated eye movements.
- Alexandro D. Ramirez
- & Emre R. F. Aksay
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Article
| Open AccessCentral amygdala micro-circuits mediate fear extinction
The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impairs fear extinction.
- Nigel Whittle
- , Jonathan Fadok
- & Stéphane Ciocchi
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Article
| Open AccessReduction of corpus callosum activity during whisking leads to interhemispheric decorrelation
Interhemispheric correlations are mediated by the corpus callosum, an extensive fiber bundle connecting the cortical hemispheres. The authors show that interhemispheric correlations between the somatosensory cortices of awake mice are reduced during whisking as a result of lower callosal activity.
- Yael Oran
- , Yonatan Katz
- & Ilan Lampl
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Article
| Open AccessMouse visual cortex contains a region of enhanced spatial resolution
The representation of space in mouse visual cortex was considered to be relatively uniform. The authors show that mice have improved visual resolution in a cortical region representing a location in space directly in front and slightly above them, showing that the representation of space in mouse visual cortex is non-uniform.
- Enny H. van Beest
- , Sreedeep Mukherjee
- & Matthew W. Self
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Article
| Open AccessOrganization of the inputs and outputs of the mouse superior colliculus
The superior colliculus (SC) receives diverse cortical inputs to drive many behaviors. Here, based on comprehensive mapping of cortico-tectal projections, the authors refined the superior colliculus into medial, centromedial, centrolateral, and lateral zones, and characterized the input-output connectivity and morphology of neurons in each zone that serve the role of SC in goal-directed behaviors.
- Nora L. Benavidez
- , Michael S. Bienkowski
- & Hong-Wei Dong
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Article
| Open AccessIn silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations
Voltage-sensitive dye imaging (VSDI) is a powerful technique for measuring membrane potential dynamics of neurons but the effective resolution is limited. Here, the authors developed an in silico model of VSDI to probe activity in a biologically detailed reconstruction of rodent neocortical microcircuits.
- Taylor H. Newton
- , Michael W. Reimann
- & Henry Markram
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| Open AccessThe insulo-opercular cortex encodes food-specific content under controlled and naturalistic conditions
Animal studies have shown that insulo-opercular network function is critical in gustation and in behaviour based on anticipated food availability. The authors describe activities within the human insulo-opercular cortex which underlie anticipatory food evaluation in both controlled and naturalistic settings.
- Yuhao Huang
- , Bina W. Kakusa
- & Casey H. Halpern
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Article
| Open AccessThe functional organization of excitatory synaptic input to place cells
Hippocampal place cells contribute to navigation and memory formation. Here, the authors use in vivo glutamate imaging to reveal patterns of excitatory input received by place cell dendrites and find more spatially tuned and functionally organized inputs arriving in the place field.
- Michael D. Adoff
- , Jason R. Climer
- & Daniel A. Dombeck
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| Open AccessDelineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice
Active responses to stressors involve motor planning, execution, and feedback. The authors identify a neuronal projection from the insular cortex to the bed nucleus of the stria terminalis that is activated during motor struggling in response to restraint stress as a potential active coping response.
- Joseph R. Luchsinger
- , Tracy L. Fetterly
- & Samuel W. Centanni
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| Open AccessDeciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding
Neuronal signaling has an important role in the regulation of energy expenditure and body weight, however, the underlying mechanisms are incompletely understood. Here, the authors report a AgRP-MC4R-serotonin expressing neuronal circuit that regulate energy expenditure without affecting feeding.
- Yong Han
- , Guobin Xia
- & Qi Wu
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Article
| Open AccessVentral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.
- Daniel C. Lowes
- , Linda A. Chamberlin
- & Alexander Z. Harris
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Article
| Open AccessAdaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity
Neural probes for experimental studies can cause tissue damage. Here the authors describe a probe incorporated with a hydrogel structure for adaptive bending stiffness to enable insertion to the rodent brain while minimising tissue damage.
- Seongjun Park
- , Hyunwoo Yuk
- & Polina Anikeeva
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Article
| Open AccessOxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats
Aggression in females is understudied in model organisms. Here, the authors establish a model of enhanced aggression in virgin female rats and show that oxytocin and vasopressin systems differentially modulate aggression in distinct neuronal populations of the lateral septum of female rats.
- Vinícius Elias de Moura Oliveira
- , Michael Lukas
- & Inga D. Neumann
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Article
| Open AccessConnectivity characterization of the mouse basolateral amygdalar complex
The basolateral amygdala is implicated in several behavior-related states including anxiety, autism, and addiction. The authors apply circuit-level pathway tracing methods combined with computational techniques to provide a comprehensive connectivity atlas of the mouse basolateral amygdala complex.
- Houri Hintiryan
- , Ian Bowman
- & Hong-Wei Dong
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Article
| Open AccessCellular connectomes as arbiters of local circuit models in the cerebral cortex
Large-scale connectomes from the mammalian brain are becoming available, but it remains unclear how informative these are for the distinction of circuit models. Here, the authors use connectome statistics to test competing models of local cortical circuits with approximate Bayesian computation.
- Emmanuel Klinger
- , Alessandro Motta
- & Moritz Helmstaedter
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Article
| Open AccessPosterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice
Innate and learned fear can induce rapid changes in body temperature of mammals. The authors identify the posterior subthalamic nucleus as a major thermoregulatory hub that connects the external lateral parabrachial subnucleus to the nucleus of the solitary tract to mediate fear-evoked hypothermia.
- Can Liu
- , Chia-Ying Lee
- & Qinghua Liu
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| Open AccessA cortico-collicular pathway for motor planning in a memory-dependent perceptual decision task
Duan, Pan et al. find that the premotor cortex cooperates with the midbrain superior colliculus via direct projections to implement decision maintenance. These results reveal mechanisms of cortico-collicular interaction during cognition and action in a pathway- and cell-type-specific manner.
- Chunyu A. Duan
- , Yuxin Pan
- & Ning-long Xu
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Article
| Open AccessBreathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation
Combining optogenetics, behavioral modelling and neural population analysis, the authors show in mice that during fear-related freezing the olfactory bulb transmits 4 Hz breathing rhythm to the prefrontal cortex where this oscillation organizes local activity and regulates freezing episode duration.
- Sophie Bagur
- , Julie M. Lefort
- & Karim Benchenane
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Article
| Open AccessLearning with reinforcement prediction errors in a model of the Drosophila mushroom body
Dopamine neurons in the mushroom body help Drosophila learn to approach rewards and avoid punishments. Here, the authors propose a model in which dopaminergic learning signals encode reinforcement prediction errors by utilising feedback reinforcement predictions from mushroom body output neurons.
- James E. M. Bennett
- , Andrew Philippides
- & Thomas Nowotny
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Article
| Open AccessA hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
Animals constantly balance seeking food with avoiding predators. Here, the authors report that CRF positive neurons in the paraventricular thalamus projecting to the nucleus accumbens in rats are an indispensable component of a feedback circuit that can interrupt appetitive behaviour in favor of a defensive response in the presence of a competing threat stimulus.
- D. S. Engelke
- , X. O. Zhang
- & F. H. Do-Monte
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Article
| Open AccessEfferent feedback controls bilateral auditory spontaneous activity
Spontaneous activity generated in the cochleae propagates into the central auditory system to promote circuit formation before hearing onset. Here, the authors reveal the important role of cholinergic efferent modulation in coordinating bilateral spontaneous activity and the emergence of functional responses.
- Yixiang Wang
- , Maya Sanghvi
- & Michael Crair
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Article
| Open AccessSight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
Parasitoids exploit host bodies for reproduction, selecting for host defences. A new host defence is reported, in which adult Drosophila accelerate mating behaviour at the sight of certain parasitoid wasps, mediated by the upregulation of a nervous system gene that encodes a 41-amino acid micropeptide.
- Shimaa A. M. Ebrahim
- , Gaëlle J. S. Talross
- & John R. Carlson
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Article
| Open AccessSingle cell plasticity and population coding stability in auditory thalamus upon associative learning
How thalamic sensory relays participate in plasticity upon associative fear learning and stable long-term sensory coding remains unknown. The authors show that auditory thalamus neurons exhibit heterogeneous plasticity patterns after learning while population level encoding of auditory stimuli remains stable across days.
- James Alexander Taylor
- , Masashi Hasegawa
- & Jan Gründemann
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| Open AccessChromatic micromaps in primary visual cortex
Stimulus feature maps are found in primary visual cortex of many species. Here the authors show color maps in trichromatic primates containing segregated ensembles of neurons with distinct chromatic signatures that associate with cortical modules known as blobs.
- Soumya Chatterjee
- , Kenichi Ohki
- & R. Clay Reid
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Article
| Open AccessMitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, though underlying mechanisms remain unknown. Here the authors show that endogenously produced hydrogen peroxide originating from axonal mitochondria functions as a signaling cue to selectively regulate neuropeptide secretion in C. elegans.
- Qi Jia
- & Derek Sieburth
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Perspective
| Open AccessToward integrative approaches to study the causal role of neural oscillations via transcranial electrical stimulation
Transcranial electrical stimulation techniques may enable exploration of the role of neural oscillations in the brain. Here, the authors provide a perspective on its potential across systems, species, theoretical and experimental scales.
- Valeriia Beliaeva
- , Iurii Savvateev
- & Rafael Polania
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Article
| Open AccessRobustness and plasticity in Drosophila heat avoidance
Simões, Levy et al. use a combination of experiments and models to study how Drosophila flies steer away from dangerous heat. They discover that flies use small temperature differences between the antennae to turn clear of thermal danger; they also demonstrate that heat avoidance, a simple innate behavior, contains unexpected plasticity.
- José Miguel Simões
- , Joshua I. Levy
- & Marco Gallio
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Article
| Open AccessA continuum of invariant sensory and behavioral-context perceptual coding in secondary somatosensory cortex
The secondary somatosensory cortex represents a range of invariant sensory responses and perceptual categorical codes across the population, with a continuum of mixed dynamics that abstractly depend on task‐demand, although the sensory representations remain unaltered.
- Román Rossi-Pool
- , Antonio Zainos
- & Ranulfo Romo
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Article
| Open AccessBi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum
This study presents an anatomical, neurophysiological and functional characterization of four distinct prefrontal populations that project to striatal and thalamic sub-regions. The authors show that each of these populations have a discrete role in the regulation of cognitive control.
- Sybren F. de Kloet
- , Bastiaan Bruinsma
- & Huibert D. Mansvelder
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Article
| Open AccessA critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy
Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy.
- Zane R. Lybrand
- , Sonal Goswami
- & Jenny Hsieh
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Article
| Open AccessFlexible categorization in perceptual decision making
Attractor networks and drift diffusion models are two approaches to model the perceptual decision making process. Here, the authors identify an intermediate regime only for the attractor model that allows flexible categorization of two choice decisions for long duration and noisy stimuli and validate these model predictions with psychophysical experiments.
- Genís Prat-Ortega
- , Klaus Wimmer
- & Jaime de la Rocha
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Article
| Open AccessCorticostriatal control of defense behavior in mice induced by auditory looming cues
Innate defense behaviours in animals in response to approaching threats are mostly studied in response to visual stimuli. Here, the authors show that looming sounds elicit stereotypical sequential defensive reactions that require the auditory cortex, superior colliculus and the striatum.
- Zhong Li
- , Jin-Xing Wei
- & Li I. Zhang
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Article
| Open AccessMouse entorhinal cortex encodes a diverse repertoire of self-motion signals
Here, the authors show that mouse medial entorhinal cortex encodes three-dimensional head movement as well as eye position and velocity. These self-motion signals are represented conjunctively in individual neurons alongside body position, running speed, and azimuthal head direction.
- Caitlin S. Mallory
- , Kiah Hardcastle
- & Lisa M. Giocomo
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Article
| Open Access3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
Currently technologies for monitoring and controlling neural activities in 3D models are lacking. Here the authors report a 3D high-density multielectrode array, with optical stimulation and drug delivery, to investigate neural circuit dynamics in engineered 3D neural tissues.
- Hyogeun Shin
- , Sohyeon Jeong
- & Il-Joo Cho
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Article
| Open AccessNon-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence
Aberrant synchronous oscillations have been associated with numerous brain disorders, including essential tremor. The authors show that synchronous cerebellar activity can casually affect essential tremor and that its underlying mechanism may be related to the temporal coherence of the tremulous movement.
- Sebastian R. Schreglmann
- , David Wang
- & Nir Grossman
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Article
| Open AccessTime-frequency super-resolution with superlets
Identifying the frequency, temporal location, duration, and amplitude of finite oscillation packets in neurophysiological signals with high precision is challenging. The authors present a method based on multiple wavelets to improve the detection of localized time-frequency packets.
- Vasile V. Moca
- , Harald Bârzan
- & Raul C. Mureșan