Featured
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Article
| Open Access
Converting an allocentric goal into an egocentric steering signal
In Drosophila, FC2 neurons signal a navigational goal, which is compared with the fly’s heading by PFL3 neurons to guide moment-to-moment steering.
- Peter Mussells Pires
- , Lingwei Zhang
- & Gaby Maimon
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Article
| Open Access
Transforming a head direction signal into a goal-oriented steering command
Here we show how PFL2 and PFL3 neurons in the Drosophila brain compare a representation of direction with internal spatial goals, both anchored in world-centric coordinates, and produce body-centric steering commands that act to correct deviations from the goal direction.
- Elena A. Westeinde
- , Emily Kellogg
- & Rachel I. Wilson
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Article
| Open Access
Dopamine promotes head direction plasticity during orienting movements
A study demonstrates that plasticity in the head direction system in Drosophila is modulated by dopamine, which increases learning when reorienting movements are bringing in new spatial information.
- Yvette E. Fisher
- , Michael Marquis
- & Rachel I. Wilson
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Article |
Odour motion sensing enhances navigation of complex plumes
Odour motion contains valuable directional information that is absent from the airflow alone, and Drosophila use this directional information to shape their navigational decisions.
- Nirag Kadakia
- , Mahmut Demir
- & Thierry Emonet
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Article
| Open Access
Fos ensembles encode and shape stable spatial maps in the hippocampus
Fos-expressing hippocampal neurons form highly correlated ensembles that contribute to spatial coding by forming reliable, long-lasting and spatially unbiased maps of an environment.
- Noah L. Pettit
- , Ee-Lynn Yap
- & Christopher D. Harvey
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Article |
Building an allocentric travelling direction signal via vector computation
A neural circuit for implementing a coordinate transformation and 2D vector computation is described in Drosophila.
- Cheng Lyu
- , L. F. Abbott
- & Gaby Maimon
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Article |
Generation of stable heading representations in diverse visual scenes
Two-photon calcium imaging and optogenetic experiments in tethered flying flies, combined with modelling, demonstrate how the correlation of compass and visual neurons underpins plasticity that enables the transformation of visual cues into stable heading representations.
- Sung Soo Kim
- , Ann M. Hermundstad
- & Vivek Jayaraman
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Letter |
Recalibration of path integration in hippocampal place cells
Evidence from hippocampal place cells shows that path-integration gain, previously thought to be a constant factor in the computation of location, is flexible and can be rapidly fine-tuned.
- Ravikrishnan P. Jayakumar
- , Manu S. Madhav
- & James J. Knierim
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Letter |
A novel mechanism for mechanosensory-based rheotaxis in larval zebrafish
In the absence of visual information, larval zebrafish (Danio rerio) use their mechanosensory lateral line to perform rheotaxis by using flow velocity gradients as navigational cues.
- Pablo Oteiza
- , Iris Odstrcil
- & Florian Engert
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Article |
A neural circuit architecture for angular integration in Drosophila
A neural circuit in Drosophila reveals how the fly’s internal sense of heading rotates when it turns.
- Jonathan Green
- , Atsuko Adachi
- & Gaby Maimon
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Article |
Neural dynamics for landmark orientation and angular path integration
Calcium imaging of the brain of tethered flies walking in a virtual reality arena showed that a population of neurons with dendrites that tile the ‘ellipsoid body’ use information from visual landmarks and the fly's own rotation to compute heading; this suggests insects possess neurons with similarities to ‘head direction cells’ known to contribute to spatial navigation in mammalian brains.
- Johannes D. Seelig
- & Vivek Jayaraman
Synaptic wiring motifs in posterior parietal cortex support decision-making