Myelodysplastic syndrome articles within Nature

Featured

• Article
  01 June 2022 | Open Access

  The longitudinal dynamics and natural history of clonal haematopoiesis

  A long-term study of 385 human donors reports that driver gene mutations and age determine the lifelong dynamics of clonal haematopoiesis

  • Margarete A. Fabre
  • , José Guilherme de Almeida
  •  & George S. Vassiliou

• Letter | 24 February 2016

  Structural basis of lenalidomide-induced CK1α degradation by the CRL4^CRBN ubiquitin ligase

  Thalidomide and its derivative lenalidomide bind the CRL4^CRBN E3 ubiquitin ligase and target protein substrates for degradation; structural and functional data determined here show that casein kinase 1α and the lymphoid transcription factor Ikaros, the efficacy targets of lenalidomide in two different blood cancers, interact with the CRBN–lenalidomide interface through a β-hairpin destruction motif.

  • Georg Petzold
  • , Eric S. Fischer
  •  & Nicolas H. Thomä

• Article | 01 July 2015

  Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

  Lenalidomide, a derivative of thalidomide, is an effective drug for myelodysplastic syndrome; lenalidomide binds the CRL4^CRBN E3 ubiquitin ligase and promotes degradation of casein kinase 1a, on which the malignant cells rely for survival.

  • Jan Krönke
  • , Emma C. Fink
  •  & Benjamin L. Ebert

• Article | 11 September 2011

  Frequent pathway mutations of splicing machinery in myelodysplasia

  • Kenichi Yoshida
  • , Masashi Sanada
  •  & Seishi Ogawa