Featured
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Article |
A gut-derived metabolite alters brain activity and anxiety behaviour in mice
The gut-derived molecule 4-ethylphenol influences complex behaviours in mice through effects on oligodendrocyte function and myelin patterning in the brain.
- Brittany D. Needham
- , Masanori Funabashi
- & Sarkis K. Mazmanian
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Article |
Suppression of proteolipid protein rescues Pelizaeus–Merzbacher disease
In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.
- Matthew S. Elitt
- , Lilianne Barbar
- & Paul J. Tesar
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Letter |
Dynamics of oligodendrocyte generation in multiple sclerosis
There are no new oligodendrocytes in potentially remyelinated multiple sclerosis shadow plaques, although oligodendrocyte generation is increased in the normal appearing white matter of patients with aggressive disease, informing the development of new therapies.
- Maggie S. Y. Yeung
- , Mehdi Djelloul
- & Jonas Frisén
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Letter |
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination
Many small molecules that stimulate oligodendrocyte formation act not through their canonical pathways but by inhibiting enzymes within the cholesterol biosynthesis pathway and thereby inducing the accumulation of 8,9-unsaturated sterols.
- Zita Hubler
- , Dharmaraja Allimuthu
- & Drew J. Adams
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Letter |
Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination
A subset of adult neural stem cells, responsive to sonic hedgehog, are more effective at remyelination when the transcription factor Gli1 is inhibited.
- Jayshree Samanta
- , Ethan M. Grund
- & James L. Salzer
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Letter |
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Two drugs, miconazole and clobetasol, have functions that modulate differentiation of oligodendrocyte progenitor cells directly, enhance remyelination, and significantly reduce disease severity in mouse models of multiple sclerosis.
- Fadi J. Najm
- , Mayur Madhavan
- & Paul J. Tesar
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News & Views |
The wrap that feeds neurons
The myelin sheath around nerve fibres serves to speed up electrical nerve signals. But it turns out that it also supplies neurons with fuel to support their high metabolic activity. See Article p.443
- Johanne E. Rinholm
- & Linda H. Bergersen
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Research Highlights |
Protein brings death to myelin
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Research Highlights |
Neurobiology: Prions at work
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Myelination and support of axonal integrity by glia