Molecular biology

Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic acids and proteins that carry out the biological processes essential for the cells functions and maintenance.

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News & Views | 11 August 2022

Landscape of somatic mutations in aging human heart muscle cells

Nature Aging, 1-2
News & Views | 10 August 2022

Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST
- Conner L. Olson
- , Alexandra T. Barbour
- & Deborah S. Wuttke
Nature Structural & Molecular Biology 29, 730-733
News & Views | 10 August 2022

A map of the human heart after myocardial infarction

Nature

Latest Research and Reviews

Research
11 August 2022 | Open Access

CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome

Viruses completely depend on the host translational machinery, but their genomes are often enriched in rare codons and therefore should be translated with poor efficiency. Here, Jungfleisch et al. apply Ribo-Seq and RNASeq to provide a global view on the translational changes occurring during Chikungunya virus (CHIKV) infection. CHIKV infection induces a codon-specific reprogramming of the host translation machinery to favor the translation of viral RNA genomes over host mRNAs via tRNA modification.
- Jennifer Jungfleisch
- , René Böttcher
- & Juana Díez
Nature Communications 13, 4725
Research
11 August 2022 | Open Access

Consensus genomic regions associated with multiple abiotic stress tolerance in wheat and implications for wheat breeding
- Mohammad Jafar Tanin
- , Dinesh Kumar Saini
- & Achla Sharma
Scientific Reports 12, 13680
Research | 11 August 2022

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Several engineered Cas13 variants achieve targeted RNA degradation with minimal collateral effects.
- Huawei Tong
- , Jia Huang
- & Hui Yang
Nature Biotechnology, 1-12
Research
11 August 2022 | Open Access

Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells

As CRISPR-based therapies enter the clinic, evaluation of safety remains a critical and active area of study. Here the authors use next generation sequencing to achieve high sequencing depth and demonstrate that clinically relevant delivery of high-fidelity Cas9 to primary HSPCs and ex vivo culture up to 10 days does not introduce or enrich for tumorigenic variants.
- M. Kyle Cromer
- , Valentin V. Barsan
- & Matthew H. Porteus
Nature Communications 13, 4724
Research
11 August 2022 | Open Access

Transcription-coupled and epigenome-encoded mechanisms direct H3K4 methylation

Methylation of histone H3 lysine 4 is associated with transcription. Here the authors describe three Arabidopsis methyltransferases that direct H3K4me1 and propose that one methyltransferase works co-transcriptionally while the others are recruited to genomic and epigenomic features.
- Satoyo Oya
- , Mayumi Takahashi
- & Soichi Inagaki
Nature Communications 13, 4521
Research | 11 August 2022

Artificial intelligence uncovers carcinogenic human metabolites

Metabokiller is a novel, explainable AI-backed method for carcinogenicity prediction that leverages the biological and chemical properties associated with carcinogens.
- Aayushi Mittal
- , Sanjay Kumar Mohanty
- & Gaurav Ahuja
Nature Chemical Biology, 1-10

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News and Comment

News & Views | 11 August 2022

Landscape of somatic mutations in aging human heart muscle cells

Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.

Nature Aging, 1-2
Research Highlights | 10 August 2022

‘Poisoning’ of the transcriptome by ultraconserved elements

Leclair and Anczuków describe how high-throughput screens uncovered the connection between poison exons and cancer.
- Nathan K. Leclair
- & Olga Anczuków
Nature Reviews Molecular Cell Biology, 1
News & Views | 10 August 2022

Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST

CST is both an ssDNA-binding complex and a DNA Pol-α/primase cofactor that coordinates the switch from G-strand elongation to C-strand fill-in during telomere maintenance. Four papers in Nature Structural & Molecular Biology and Nature provide transformative insights into CST activity, providing a platform to understand lagging-strand synthesis genome wide.
- Conner L. Olson
- , Alexandra T. Barbour
- & Deborah S. Wuttke
Nature Structural & Molecular Biology 29, 730-733
Editorial
10 August 2022 | Open Access

Molecular explorations of cancer biology and therapeutics at PDB-101
- David S. Goodsell
- , Shuchismita Dutta
- & Stephen K. Burley
Oncogene, 1-3
News & Views | 10 August 2022

A map of the human heart after myocardial infarction

Myocardial infarction, or heart attack, is one of the world’s biggest killers. An analysis of spatial and single-cell changes to human tissue after a heart attack provides insights into disease mechanisms and builds a resource for the discovery of therapeutics.

Nature
Research Highlights | 09 August 2022

Surprise neurovascular dysfunction in frontotemporal dementia

Neurovascular function is altered in one form of autosomal-dominant frontotemporal dementia (FTD), according to new research.
- Ian Fyfe
Nature Reviews Neurology, 1

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Molecular biology

Featured

Landscape of somatic mutations in aging human heart muscle cells

Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST

A map of the human heart after myocardial infarction

Latest Research and Reviews

CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome

Consensus genomic regions associated with multiple abiotic stress tolerance in wheat and implications for wheat breeding

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells

Transcription-coupled and epigenome-encoded mechanisms direct H3K4 methylation

Artificial intelligence uncovers carcinogenic human metabolites

News and Comment

Landscape of somatic mutations in aging human heart muscle cells

‘Poisoning’ of the transcriptome by ultraconserved elements

Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST

Molecular explorations of cancer biology and therapeutics at PDB-101

A map of the human heart after myocardial infarction

Surprise neurovascular dysfunction in frontotemporal dementia

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