Model vertebrates

Model vertebrates are extensively studied non-human vertebrates (species with a notochord, or vertebral column) chosen for the ease of investigating particular biological phenomena in areas such as development, physiology or disease. Research on model vertebrates provides insights that are relevant to other organisms, often including humans.

Latest Research and Reviews

  • Research |

    Antigen-specific CD8+ T cells can be imaged by immunoPET with the help of synTacs, MHC-based tools that bind to relevant T-cell receptors.

    • Andrew W. Woodham
    • , Stad H. Zeigler
    • , Ella L. Zeyang
    • , Stephen C. Kolifrath
    • , Ross W. Cheloha
    • , Mohammad Rashidian
    • , Rodolfo J. Chaparro
    • , Ronald D. Seidel
    • , Scott J. Garforth
    • , Jason L. Dearling
    • , Maia Mesyngier
    • , Phaneendra K. Duddempudi
    • , Alan B. Packard
    • , Steven C. Almo
    •  & Hidde L. Ploegh
  • Research
    | Open Access

    Using Nrf2 knockout mice, Suzuki, Uruno, Yumoto et al. show that space travel activates Nrf2 signaling, which contributes to the weight gain of mice by regulating fat metabolism of white adipose tissues. This study provides insights into potential interventions to mitigate stresses that accompany space travels.

    • Takafumi Suzuki
    • , Akira Uruno
    • , Akane Yumoto
    • , Keiko Taguchi
    • , Mikiko Suzuki
    • , Nobuhiko Harada
    • , Rie Ryoke
    • , Eriko Naganuma
    • , Nanae Osanai
    • , Aya Goto
    • , Hiromi Suda
    • , Ryan Browne
    • , Akihito Otsuki
    • , Fumiki Katsuoka
    • , Michael Zorzi
    • , Takahiro Yamazaki
    • , Daisuke Saigusa
    • , Seizo Koshiba
    • , Takashi Nakamura
    • , Satoshi Fukumoto
    • , Hironobu Ikehata
    • , Keizo Nishikawa
    • , Norio Suzuki
    • , Ikuo Hirano
    • , Ritsuko Shimizu
    • , Tetsuya Oishi
    • , Hozumi Motohashi
    • , Hirona Tsubouchi
    • , Risa Okada
    • , Takashi Kudo
    • , Michihiko Shimomura
    • , Thomas W. Kensler
    • , Hiroyasu Mizuno
    • , Masaki Shirakawa
    • , Satoru Takahashi
    • , Dai Shiba
    •  & Masayuki Yamamoto
  • Research |

    Red and yellow versions of the genetically encoded dopamine sensor dLight1 have been developed and allow multiplexed imaging of dopamine with neurotransmitter or cell-type-specific calcium combined with green sensors or actuators, as demonstrated ex vivo and in behaving rodents.

    • Tommaso Patriarchi
    • , Ali Mohebi
    • , Junqing Sun
    • , Aaron Marley
    • , Ruqiang Liang
    • , Chunyang Dong
    • , Kyle Puhger
    • , Grace Or Mizuno
    • , Carolyn M. Davis
    • , Brian Wiltgen
    • , Mark von Zastrow
    • , Joshua D. Berke
    •  & Lin Tian

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