Microscopy articles within Nature Genetics

Featured

• Research Highlight | 09 August 2023

  The ‘kiss and kick’ model of gene activation

  • Chiara Anania

• Article | 01 April 2021

  Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development

  Single-cell analysis of Drosophila development with Hi-M suggests that physical proximity between regulatory regions does not necessarily instruct transcriptional states. Multi-way analyses identify the existence of regulatory hubs that emerge before topologically associating domains.

  • Sergio Martin Espinola
  • , Markus Götz
  •  & Marcelo Nollmann

• Obituary | 26 September 2014

  David H. Dressler 1941–2014

  • Huntington Potter

• Research Highlights | 26 June 2014

  TM6SF2 and fat metabolism

  • Kyle Vogan

• Letter | 23 February 2014

  Direct measurement of transcription factor dissociation excludes a simple operator occupancy model for gene regulation

  Johan Elf and colleagues developed a single-molecule chase assay to measure the time a single transcription factor is bound at a specific chromosomal operator site, which they use to examine the dynamics of binding of the Lac repressor dimer at the native lac operator in Escherichia coli. Their findings do not support the simple operator occupancy model and suggest a role for non-equilibrium transcription factor kinetics in E. coli gene regulation.

  • Petter Hammar
  • , Mats Walldén
  •  & Johan Elf