Metabolomics

Metabolomics refers to the systematic identification and quantification of the small molecule metabolic products (the metabolome) of a biological system (cell, tissue, organ, biological fluid, or organism) at a specific point in time. Mass spectrometry and NMR spectroscopy are the techniques most often used for metabolome profiling.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Gomes et al. show that age-dependent upregulation of levels of the metabolite methylmalonic acid (MMA) in serum from healthy donors can promote tumour progression in mice via SOX4-dependent regulation of cell fate decisions.

    • Ulrike Harjes
  • News and Views |

    The mechanistic target of rapamycin complex 1 (mTORC1) network integrates nutrient and energy signals that regulate metabolism and cell growth. Orozco et al. now show that the glycolytic intermediate dihydroxyacetone phosphate (DHAP) relays glycolytic activity to mTORC1 signalling.

    • Gerta Hoxhaj
    • , Jason W. Locasale
    •  & Issam Ben-Sahra
    Nature Metabolism 2, 801-802
  • News and Views |

    Metabolomics can identify dietary biomarkers and describe the metabolic consequences of diet. A robust study design identifies a set of stable urinary metabolites that link to healthy and unhealthy dietary patterns, metabolic networks and distinct urinary metabolic signatures.

    • Aifric O’Sullivan
    Nature Food 1, 398-399
  • Research Highlights |

    Using a rapid mass-spectrometry based approach to analyse aerosol released during surgical cauterization of tumour tissue, Koundouros et al. derived metabolic signatures associated with the tumour genotype. Based on these signatures, they identified a new mechanism by which oncogenic PI3K signalling promotes tumour growth.

    • Ulrike Harjes