Featured
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Letter |
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Succinate is identified as a metabolite in innate immune signalling, which leads to enhanced interleukin-1β production during inflammation.
- G. M. Tannahill
- , A. M. Curtis
- & L. A. J. O’Neill
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Review Article |
Metabolic phenotyping in clinical and surgical environments
- Jeremy K. Nicholson
- , Elaine Holmes
- & John C. Lindon
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Letter |
Infection regulates pro-resolving mediators that lower antibiotic requirements
Resolvins and protectins are anti-inflammatory and pro-resolving lipid mediators that are shown to resolve infections, and their administration lowers required doses of antibiotics and shortens infections.
- Nan Chiang
- , Gabrielle Fredman
- & Charles N. Serhan
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News |
Rat helps pinpoint pain molecule
Random screen of metabolites could offer new routes to drug targets for pain relief.
- Katharine Sanderson
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Outlook |
Microbiome: That healthy gut feeling
Many ingredients in traditional herbal medicines cannot be absorbed by the human gut. Could our microbial inhabitants do for us what we can't do ourselves?
- James Mitchell Crow
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Article |
Human metabolic individuality in biomedical and pharmaceutical research
- Karsten Suhre
- , So-Youn Shin
- & Christian Gieger
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Article |
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
This paper shows that gut flora can influence cardiovascular disease, by metabolizing a dietary phospholipid. Using a metabolomics approach it is found that plasma levels of three metabolites of dietary phosphatidylcholine—choline, betaine and TMAO—are associated with increased risk of cardiovascular disease in humans. The gut flora is known to have a role in TMAO formation from choline, and this paper shows that dietary choline supplementation enhances macrophage foam cell formation and lesion formation in atherosclerosis-prone mice, but not if the gut flora are depleted with antibiotics.
- Zeneng Wang
- , Elizabeth Klipfell
- & Stanley L. Hazen
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Research Highlights |
Physiology: Marathon metabolites
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News |
The metabolic secrets of good runners
Chemical changes in runners linked to physical fitness.
- Heidi Ledford