Metabolism refers to the chemical reactions that occur within an organism to sustain life. The reactions are divided into two categories: catabolism (the breakdown of organic matter to produce energy); and anabolism (the construction of molecules from smaller units).


Latest Research and Reviews

News and Comment

  • News and Views |

    The molecular mechanisms responsible for initiation and progression of osteoarthritis (OA) are incompletely understood. New data implicate cholesterol, its metabolites and the receptor RORα as catabolic drivers of OA-like disease in mice, but do these data identify new targets for treating patients with OA?

    • Frank Beier
  • Comments and Opinion |

    Lifestyle-associated pathologies have reached epidemic proportions and urgent action is needed to protect the public from unhealthy diets. Here, the authors describe how the Western diet has long-lasting effects on the immune system that promote chronic metabolic inflammatory diseases.

    • Anette Christ
    •  & Eicke Latz
  • Comments and Opinion |

    The Chinese Famine has been widely interpreted as an important contributor to subsequent epidemics of type 2 diabetes mellitus. Our re-examination of available studies challenges this apparent relationship. The definition of famine exposure and control selection needs more attention in future studies to better understand this potential association.

    • Chihua Li
    • , Elmar W. Tobi
    • , Bastiaan T. Heijmans
    •  & L. H. Lumey
  • News and Views |

    The quality of carbohydrate-rich foods rather than quantity has the strongest effect on major health outcomes. Systematic reviews and meta-analyses of prospective studies report lower mortality and reduced incidence of cardiovascular diseases, type 2 diabetes mellitus and colorectal cancer in people who habitually consume diets rich in fibre and whole grain.

    • Gabriele Riccardi
    •  & Giuseppina Costabile