Metabolic pathways articles from across Nature Portfolio

Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. The glycolysis and Krebs cycle metabolic pathways, in aerobic respiration, produce precursors of various important cellular molecules such as the primary metabolite ATP; other metabolic pathways produce secondary metabolites.

Latest Research and Reviews

News and Comment

  • News & Views |

    Bacterial biofilms are resilient multicellular communities with spatially complex localized interactions that remain largely uncharacterized. A new approach called RainbowSeq enables transcriptional profiling in biofilms with increased spatial resolution.

    • Maria Hadjifrangiskou
  • News & Views |

    The NADP+/NADPH coenzyme couple powers cellular biosynthesis and oxidative defense. A new study tracing glucose-derived deuterium during proline biosynthesis analyzes subcellular perturbations in NADPH utilization, revealing that NADP+/NADPH coenzyme pools in the cytosol and mitochondria are regulated independently.

    • Justin R. Cross
  • News & Views |

    Comamonas testosteroni utilizes aromatic compounds such as monomers from lignin and plastics, but the underlying metabolic pathways were elusive. Multi-omics analysis now clarifies the multifaceted regulation of its metabolism, facilitating strain engineering to convert substrates from lignin and plastics into valuable bioproducts.

    • Yinjie J. Tang
    •  & Tae Seok Moon
  • News & Views |

    Inspired by nature, a synthetic carbon fixation cycle builds complex molecules directly from CO2. Building metabolism from the ground up requires several innovative advancements — now, a strategy to balance carbon demands in a complex metabolic network is explored.

    • Grant M. Landwehr
    •  & Michael C. Jewett