The NADP+/NADPH coenzyme couple powers cellular biosynthesis and oxidative defense. A new study tracing glucose-derived deuterium during proline biosynthesis analyzes subcellular perturbations in NADPH utilization, revealing that NADP+/NADPH coenzyme pools in the cytosol and mitochondria are regulated independently.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Niu, X. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01283-9 (2023).
MacDonald, M. J. J. Biol. Chem. 270, 20051–20058 (1995).
Ronnebaum, S. M. et al. J. Biol. Chem. 281, 30593–30602 (2006).
Veech, R. L., Todd King, M., Pawlosky, R., Kashiwaya, Y., Bradshaw, P. C. & Curtis, W. IUBMB Life 71, 565–579 (2019).
Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B. & Rabinowitz, J. D. Nature 510, 298–302 (2014).
Lewis, C. A. et al. Mol. Cell 55, 253–263 (2014).
Cracan, V., Titov, D. V., Shen, H., Grabare, K. Z. & Mootha, V. K. Nat. Chem. Biol. 13, 1088–1095 (2017).
Dufner, D. & Previs, S. F. Curr. Opin. Clin. Nutr. Metab. Care 6, 511–517 (2003).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Cross, J.R. Reporting NADPH fluxes. Nat Chem Biol 19, 792–794 (2023). https://doi.org/10.1038/s41589-023-01298-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-023-01298-2