Medicinal chemistry

Medicinal chemistry deals with the design, optimization and development of chemical compounds for use as drugs. It is inherently a multidisciplinary topic — beginning with the synthesis of potential drugs followed by studies investigating their interactions with biological targets to understand the medicinal effects of the drug, its metabolism and side-effects.

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News and Comment

  • News and Views |

    Methods for generating molecular diversity provide a route to screen a wider section of chemical space, to discover compounds with useful biological properties. Now, a complexity-to-diversity strategy has enabled the discovery of a multi-cyclic structure from a complex natural product that induces ferroptotic cell death in cancer cells.

    • Tatiana Cañeque
    •  & Raphaël Rodriguez
    Nature Chemistry 11, 499-500
  • News and Views |

    A simple chemical modification can substantially reduce the toxicity of antisense oligonucleotides.

    • Arthur M. Krieg
  • Comments and Opinion | | open

    The number of chemical compounds and associated experimental data in public databases is growing, but presently there is no simple way to access these data in a quick and synoptic manner. Instead, data are fragmented across different resources and interested parties need to invest invaluable time and effort to navigate these systems.

    • Sten Ilmjärv
    • , Fiona Augsburger
    • , Jerven Tjalling Bolleman
    • , Robin Liechti
    • , Alan James Bridge
    • , Jenny Sandström
    • , Vincent Jaquet
    • , Ioannis Xenarios
    •  & Karl-Heinz Krause
  • News and Views |

    Endocytosis mediates the internalization of proteins and lipids at the plasma membrane and plays essential roles in plant growth and development. A new small molecule enables manipulation of plant endocytosis in an acute and transient manner.

    • Chunhua Zhang
    •  & Glenn R. Hicks