Medical research articles from across Nature Portfolio

Medical research involves research in a wide range of fields, such as biology, chemistry, pharmacology and toxicology with the goal of developing new medicines or medical procedures or improving the application of those already available. It can be viewed as encompassing preclinical research (for example, in cellular systems and animal models) and clinical research (for example, clinical trials).

Featured

News & Views | 22 March 2023

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

Nature Metabolism 5, 368-369
News & Views | 22 March 2023

Cancer cells remodel nuclear actin filaments to resist chemotherapy
- Stephanie Panier
Nature
News & Views | 20 March 2023

Estimation of cross-ancestry genetic correlations within ancestry tracts of admixed samples
- Elizabeth G. Atkinson
Nature Genetics, 1-3

Latest Research and Reviews

Research
24 March 2023 | Open Access

40 years of actigraphy in sleep medicine and current state of the art algorithms
- Matthew R. Patterson
- , Adonay A. S. Nunes
- & Christine C. Guo
npj Digital Medicine 6, 51
Research
24 March 2023 | Open Access

A population-based nomogram to individualize treatment modality for pancreatic cancer patients underlying surgery
- Xiao-Ya Shi
- , Yan Wang
- & Bai Wei
Scientific Reports 13, 4856
Research
24 March 2023 | Open Access

Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants

Here the authors describe a small antibody-like protein that can prevent infection by diverse SARS-CoV-2 variants in cell culture and in mice that were intranasally treated with this inhibitor before or shortly after being exposed to the virus.
- Anna R. Mäkelä
- , Hasan Uğurlu
- & Kalle Saksela
Nature Communications 14, 1637
Reviews | 24 March 2023

Calcium signalling pathways in prostate cancer initiation and progression

In this Review, the authors provide an overview of the role of calcium as a driver of prostate cancer onset and progression, and discuss the most current therapies targeting the calcium signalling machinery to treat this malignancy.
- Roberto Silvestri
- , Vanessa Nicolì
- & Martin D. Bootman
Nature Reviews Urology, 1-20
Research
24 March 2023 | Open Access

Experimental and theoretical studies for corrosion of molybdenum electrode using streptomycin drug in phosphoric acid medium
- Shymaa S. Medany
- , Yahia H. Ahmad
- & Amany M. Fekry
Scientific Reports 13, 4827
Research
24 March 2023 | Open Access

Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial
- Sunil S. Patel
- , David R. Lally
- & Arshad M. Khanani
Eye, 1-7

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News and Comment

Research Highlights | 24 March 2023

Gene editing holds promise for babies with deadly immune disease

Repairs to DNA allow stem cells to develop into T cells.

Nature
Correspondence
24 March 2023 | Open Access

CD19/CD22 bispecific CAR-T cells for MRD-positive adult B cell acute lymphoblastic leukemia: a phase I clinical study
- Jiahua Niu
- , Huiying Qiu
- & Xianmin Song
Blood Cancer Journal 13, 44
Research Highlights | 23 March 2023

Telemonitoring for complicated pregnancies

According to a randomized trial, home-based monitoring of complicated pregnancies could be a safe alternative to hospital admission.
- Karen O’Leary
Nature Medicine
Research Highlights | 23 March 2023

Reservoirs of allergic memory

Two preprints by Koenig et al. and Ota et al. characterize a subset of memory B cells that can retain allergen-specific IgE memory.
- Michelle Tran
- & Cecilia Berin
Nature Reviews Immunology, 1
Comments & Opinion | 22 March 2023

The future German Center for Mental Health (Deutsches Zentrum für Psychische Gesundheit): a model for the co-creation of a national translational research structure

Moving the needle in mental health research requires doing justice to the social, psychological, biological and developmental complexities that affect people in their living environments. We developed a comprehensive national research program to achieve scale and depth through translational project bundles focused on early recognition and prevention, urban mental health, and enhanced psychotherapy, underpinned by a range of shared infrastructures. The program was consistently co-created with and will involve people with lived experience at all stages of research.
- Andreas Meyer-Lindenberg
- , Peter Falkai
- & Andreas Heinz
Nature Mental Health 1, 153-156
News & Views | 22 March 2023

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

PCYT2 is an enzyme involved in lipid biosynthesis, and its genetic deficiency in zebrafish, mice and humans causes progressive muscle weakness. Importantly, PCYT2 activity declines in ageing muscles of mice and humans, and PCYT2 gene therapy in aged mice improves muscle strength, suggesting new therapeutic avenues to explore for maintaining muscle health in ageing.

Nature Metabolism 5, 368-369

All News & Comment

Medical research articles from across Nature Portfolio

Featured

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

Cancer cells remodel nuclear actin filaments to resist chemotherapy

Estimation of cross-ancestry genetic correlations within ancestry tracts of admixed samples

Latest Research and Reviews

40 years of actigraphy in sleep medicine and current state of the art algorithms

A population-based nomogram to individualize treatment modality for pancreatic cancer patients underlying surgery

Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants

Calcium signalling pathways in prostate cancer initiation and progression

Experimental and theoretical studies for corrosion of molybdenum electrode using streptomycin drug in phosphoric acid medium

Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial

News and Comment

Gene editing holds promise for babies with deadly immune disease

CD19/CD22 bispecific CAR-T cells for MRD-positive adult B cell acute lymphoblastic leukemia: a phase I clinical study

Telemonitoring for complicated pregnancies

Reservoirs of allergic memory

The future German Center for Mental Health (Deutsches Zentrum für Psychische Gesundheit): a model for the co-creation of a national translational research structure

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing

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