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Featured
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Books & Arts |
Genomics: Sequence sharing
Peter Border asks how we can protect our personal genomic data while making them available for research.
- Peter Border
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News Feature |
Stem cells: The crusader
Theresa Deisher once shunned religion for science. Now, with renewed faith, she is fighting human-embryonic-stem-cell research in court.
- Meredith Wadman
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Perspective |
Charting a course for genomic medicine from base pairs to bedside
- Eric D. Green
- , Mark S. Guyer
- & Jane L. Peterson
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News |
Options for off-the-shelf blood vessels expand
Preliminary research could open the door to ready-to-use bioengineered veins.
- Tiffany O’Callaghan
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News |
Flaw in induced-stem-cell model
Adult cells do not fully convert to embryonic-like state.
- Elie Dolgin
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News & Views |
Diabetes in India
With the spread of fast-food outlets and more sedentary lifestyles, the prevalence of diabetes in India is rising alarmingly. But the subpopulations at risk and the symptoms of the disease differ from those in the West.
- Jared Diamond
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Correspondence |
Cutting random funding decisions
- Nicholas Graves
- , Adrian G. Barnett
- & Philip Clarke
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News |
France mulls embryo research reform
Scientists and clinicians push for a clearer, more permissive law on human embryonic stem-cell work.
- Declan Butler
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News |
Cells snag top modelling job
Heart disorder joins growing list of conditions getting the 'disease in a dish' treatment.
- Ewen Callaway
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Comment |
Bring on the biomarkers
The dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated 'big science' approach, argues George Poste.
- George Poste
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News |
Cancer trial errors revealed
University officials admit data withheld from review panel before misconduct charges arose.
- Eugenie Samuel Reich
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News |
UK health research to be rehabilitated
Government welcomes report on reform of 'complex and scattered' regulation.
- Daniel Cressey
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News |
From battlefield to bedside
Medical research in the British military soldiers on despite defence cuts.
- Daniel Cressey
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World View |
Drug development needs a new brand of science
We need to break with the past to develop new medicines, says Garret FitzGerald. An interdisciplinary NIH centre points the way.
- Garret FitzGerald
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News |
Slim spoils for obesity drugs
Drug makers struggle to find viable treatments for global epidemic.
- Heidi Ledford
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News Q&A |
The bridge between lab and clinic
Francis Collins makes the case for an institute focused on translational research.
- Meredith Wadman
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Career Brief |
Biomedical recruitment
Irish partnership gets €19-million government grant for diagnostics R&D.
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Editorial |
Animal instinct
Germany must better explain the scientific use of animals to remain a major biomedical force.
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News |
NIH director wins bid for translational medicine centre
New nexus will bridge basic and clinical research to improve health.
- Meredith Wadman
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News Feature |
Stem cells: The impatient advocate
Bob Klein founded the California Institute for Regenerative Medicine, the biggest state-run research project in US history. What legacy will he leave behind?
- Elie Dolgin
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Editorial |
Treated fairly?
Moves to price new pharmaceuticals sensibly shouldn't damage the industry's health.
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News |
High hopes for arthritis drugs
Race is on to develop treatments that inhibit signalling proteins.
- Heidi Ledford
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Q&A |
Turning point: Jacob Hanna
Palestinian researcher heads to Israel to foster scientific exchange.
- Virginia Gewin
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Perspective |
From maps to mechanisms through neuroimaging of schizophrenia
- Andreas Meyer-Lindenberg
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News |
Funding crisis hits US ageing research
Shortfalls hamper scientists' efforts to address a predicted epidemic of age-related diseases.
- Meredith Wadman
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News & Views |
On stress and pressure
The protein angiotensinogen must undergo conformational changes to be cleaved into a precursor of the hormone angiotensin, which increases blood pressure. Oxidative stress seems to mediate this structural alteration. See Letter p.108
- Curt D. Sigmund
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Comment |
Long shadow of the stem–cell ruling
Two months on from the court decision that briefly suspended US federal funding for human embryonic stem-cell research, uncertainty still stalks the field. Here an ethicist, a team of bankers and a lawyer warn of effects of this saga that could be felt for years to come.
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News |
Mystery fraud accusations
Stem-cell researchers targeted by e-mails from unidentified group.
- Heidi Ledford
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Career Brief |
Biomedical investment
Singapore aims to attract local and international young scientific talent.
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Research Highlights |
Drug development: Worm surgery on a chip
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Feature |
Biomedical science: Putting research into practice
Hospitals are an obvious career destination for medical doctors. But are they a good fit for basic scientists?
- Laura Bonetta
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Letter |
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
Realizing the full potential of human embryonic stem cells (hESCs) in research and clinical applications requires a detailed understanding of the genetic network that governs their unique properties. A genome-wide RNA interference screen identifies a wealth of new regulators of self-renewal and pluripotency properties in hESCs. The transcription factor PRDM14, for example, is required for the maintenance of hESC identity and reprogramming of somatic cells to pluripotency.
- Na-Yu Chia
- , Yun-Shen Chan
- & Huck-Hui Ng
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Books & Arts |
Drug development: The invisible front line
The paid participants in phase I clinical trials need more protection, finds Meredith Wadman.
- Meredith Wadman
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News |
US midterm elections: Deficit poses threat to science
Research programmes in the United States seem to be heading for a cliff, no matter who wins in Congress.
- Eugenie Samuel Reich
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News |
US midterm elections: NIH prepares for loss of political champions
Supporters call for Congress to pass stem-cell bill and NIH budget boost during post-election session.
- Meredith Wadman
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Editorial |
Stem-cell laws in China fall short
The Chinese government's regulations of stem-cell treatments are admirable in principle, but tougher enforcement measures are needed to protect patients.
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News |
Baby boom bags Nobel prize
UK pioneer of in vitro fertilization wins medicine honour.
- Alison Abbott
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Research Highlights |
Cancer biology: Sequencing guides cancer treatment
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Editorial |
Hope in translation
An increasing number of biomedical researchers are testing their ideas on people. The early-phase clinical-trial results are a promising sign of greater cooperation between scientists and clinicians.