Mass spectrometry articles within Nature Reviews Genetics

Featured

  • Review Article |

    The abundance and heterogeneity of mutations in cancer create challenges for understanding their effects, but such functional characterization will be crucial for optimizing clinical care. In this Review, the authors discuss diverse computational tools and systems biology experimental strategies for elucidating the functional effects of cancer mutations, including consequences on gene regulation, protein structure and local and global perturbations of molecular interaction networks.

    • Song Yi
    • , Shengda Lin
    •  & Nidhi Sahni

  • Review Article |

    Although it has been known for decades that RNA is subjected to numerous covalent modifications, there has been a recent surge in interest driven by sequencing-based transcriptome-wide detection methods and the realization that RNA modifications have important roles in diverse biological processes. This Review describes the range of detection strategies for RNA modifications, their particular strengths and limitations, and how responsible and complementary application of these techniques will be required to ensure the quality and interpretability of the rapidly accumulating data sets.

    • Mark Helm
    •  & Yuri Motorin

  • Review Article |

    Despite their complexity and dynamics, proteomes are starting to be comprehensively characterized; this has been made possible particularly by various technical advances in mass spectrometry. This Review highlights how proteomic studies are contributing to our understanding of various cellular processes in health and disease.

    • A. F. Maarten Altelaar
    • , Javier Munoz
    •  & Albert J. R. Heck

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