Macrophages articles within Nature Communications

Featured

• Article
  27 June 2019 | Open Access

  Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

  Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.

  • Hajime Abe
  • , Norihiko Takeda
  •  & Issei Komuro

• Article
  12 April 2019 | Open Access

  Immunoregulation of macrophages by dynamic ligand presentation via ligand–cation coordination

  Control of macrophage adhesion and phenotype is important to biomaterial applications. Here, the authors report on the use of bisphosphonate coated gold nanoparticles by magnesium coordination for the controlled adhesion and polarisation of macrophages in vitro and in vivo and controlled cell release.

  • Heemin Kang
  • , Boguang Yang
  •  & Liming Bian

• Article
  25 March 2019 | Open Access

  ZEB1 protects skeletal muscle from damage and is required for its regeneration

  Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.

  • Laura Siles
  • , Chiara Ninfali
  •  & Antonio Postigo

• Article
  16 October 2017 | Open Access

  Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle

  Exon skipping is a strategy for the treatment of Duchenne muscular dystrophy, but has variable efficacy. Here, the authors show that dystrophin restoration occurs preferentially in areas of myofiber regeneration, where antisense oligonucleotides are stored in macrophages and delivered to myoblasts and newly formed myotubes

  • James S. Novak
  • , Marshall W. Hogarth
  •  & Terence A. Partridge

• Article
  22 September 2017 | Open Access

  Macrophage-released ADAMTS1 promotes muscle stem cell activation

  Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.

  • Hongqing Du
  • , Chung-Hsuan Shih
  •  & Brian J. Feldman

• Article
  18 August 2017 | Open Access

  CD206⁺ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

  Adipose tissue contains macrophages that can influence both local and systemic metabolism via the secretion of cytokines. Here, Nawaz et al. report that M2-like macrophages, present in adipose tissue, create a microenvironment that inhibits proliferation of adipocyte progenitors due to the secretion of TGF-β1

  • Allah Nawaz
  • , Aminuddin Aminuddin
  •  & Kazuyuki Tobe

• Article
  31 March 2015 | Open Access

  Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

  The IgG sugar moiety modulates the binding of immune complexes to their Fcγ receptors resulting in pro- or anti-inflammatory response. This study shows that IgG sialylation also affects osteoclastogenesis and bone mass in mice and humans, identifying a new link between bone and the immune system.

  • Ulrike Harre
  • , Stefanie C. Lang
  •  & Georg Schett

• Article | 17 February 2015

  Primitive macrophages control HSPC mobilization and definitive haematopoiesis

  Haematopoietic stem/progenitor cells (HSPCs) transform from aortic endothelium into migratory cells that move through stroma and enter circulation to colonize haematopoietic tissues. Here the authors show that HSPCs' passage is facilitated by primitive macrophages that secrete extracellular matrix-degrading enzymes.

  • Jana Travnickova
  • , Vanessa Tran Chau
  •  & Karima Kissa