Lymphokines articles within Nature Communications

Featured

• Article
  24 January 2020 | Open Access

  YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

  Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ inducing myofibroblastic FRCs and LN fibrosis.

  • Sung Yong Choi
  • , Hosung Bae
  •  & Gou Young Koh

• Article
  09 August 2018 | Open Access

  T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

  CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.

  • Aakanksha Jain
  • , Ran Song
  •  & Chandrashekhar Pasare

• Article
  09 October 2017 | Open Access

  Transcription factor Foxo1 is essential for IL-9 induction in T helper cells

  The transcription factor Foxo1 can control regulatory T cell and Th1 function. Here the authors show that Foxo1 is also critical for IL-9 production by Th9 cells and other IL-9-producing cells.

  • Sakshi Malik
  • , Srikanth Sadhu
  •  & Amit Awasthi