Lymph node

Lymph nodes are small organs that are distributed throughout the body and drain lymph fluid from the tissues. Immune cells reside in lymph nodes and survey the lymph for signs of infection. If a tissue is infected, immune cells in the draining lymph node become activated and proliferate.

Latest Research and Reviews

News and Comment

  • News & Views |

    Multistep mechanosensing of lymphocyte infiltration and proliferation by the remodeling stroma and matrix underlies the immensely rapid and massive tissue expansion by lymph nodes in response to immune challenge.

    • Yunus Alapan
    •  & Susan N. Thomas
    Nature Immunology 23, 1139-1141
  • Research Highlights |

    Lymph node colonization by tumour cells promotes subsequent spread to distant tissues by inducing broad alterations in tumour immunity and generating tumour-specific immune tolerance.

    • Lucy Bird
  • Research Highlights |

    A paper in Nature Immunology describes a new subset of fibroblastic reticular cells, defined by expression of Gremlin 1, in lymphoid tissues that maintain homeostasis of conventional dendritic cells and ensure proper T cell immunity.

    • Lucy Bird
  • News & Views |

    Single-cell technologies reveal the building blocks of secondary lymphoid organs, identifying Grem1+ fibroblastic reticular cells (FRCs) as critical niche cells that contribute to resident dendritic cell homeostasis and T cell immunity.

    • Antonio P. Baptista
    •  & Michael Y. Gerner
    Nature Immunology 22, 541-543
  • News & Views |

    The eradication of pathogens and establishment of immunological memory depend on the generation of both effector and long-lived memory cells within specialized immune niches. Whole-organ imaging demonstrates that, during viral infection, the fate of CD8+ T cells in lymph nodes is coupled to chemotactic signals controlling their distribution within different microanatomical sites.

    • Liat Stoler-Barak
    •  & Ziv Shulman
    Nature Immunology 22, 402-403