Lupus nephritis

Lupus nephritis is an inflammatory kidney disease (glomerulonephritis) that develops in patients with systemic lupus erythematosus (SLE). In patients with SLE, the immune system is not properly regulated and attacks the bodys own tissues, causing damage to the kidneys and other organs.

Latest Research and Reviews

Research
03 September 2022 | Open Access

Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis
- Lili Zhuang
- , Xiaoqing Luo
- & Erwei Sun
Cell Death Discovery 8, 379
Research
23 August 2022 | Open Access

CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis
- Fu Lv
- , Yingxin He
- & Yuanyuan Qi
Cell Death & Disease 13, 729
Research
06 May 2022 | Open Access

CircRTN4 aggravates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis

The expression of circRTN4 is significantly enhanced in lupus nephritis. Downregulation of circRTN4 expression alleviates extracellular matrix deposition by targeting the miR-513a-5p/FN axis in cultured human renal mesangial cells and pristane-induced BALB/c mice or MRL/lpr mice. In addition, monocyte circRTN4 participates in mesangial cell dysfunction in an exosome-dependent manner. Exosomal circRTN4 mzytherefore be an effective biomarker for lupus nephritis detection and a novel therapeutic target.
- Xinyan Miao
- , Yuexin Tian
- & Shuxia Liu
Laboratory Investigation 102, 966-978
Research
30 October 2021 | Open Access

A preliminary study of KAT2A on cGAS-related immunity in inflammation amplification of systemic lupus erythematosus
- Youzhou Tang
- , Xinyu Li
- & Quan Zhuang
Cell Death & Disease 12, 1036
Research
20 July 2021 | Open Access

Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus
- Kathryn M. Kingsmore
- , Prathyusha Bachali
- & Peter E. Lipsky
Scientific Reports 11, 14789
Research
16 July 2021 | Open Access

IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development
- Guoping Shi
- , Dan Li
- & Yayi Hou
Cell Death Discovery 7, 179

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News and Comment

Research Highlights | 02 November 2022

Treatment of SLE with anti-CD19 CAR-T cells
- Ellen F. Carney
Nature Reviews Nephrology 18, 743
Research Highlights | 25 July 2022

Determining treatment response in lupus nephritis
- Susan J. Allison
Nature Reviews Nephrology 18, 543
News & Views | 06 May 2022

Interferon blockade in lupus: effects on antiviral immunity

Targeting type I interferon immune responses is a potential strategy for the treatment of systemic lupus erythematosus. Although a phase 2 clinical trial of anifrolumab did not meet its primary end point, further studies are needed to assess the effects of interferon blockade on flare rates of lupus nephritis. However, the observed higher risk of herpes zoster associated with anifrolumab use suggests that caution is warranted with this strategy.
- Stefanie Steiger
- & Hans-Joachim Anders
Nature Reviews Nephrology 18, 415-416
Research Highlights | 08 February 2022

CD6 is a therapeutic target for LN

New research identifies the CD6 ligand ALCAM as a urinary biomarker of lupus nephritis, and shows that CD6 blockade can reduce lupus nephritis disease activity.
- Robert Phillips
Nature Reviews Rheumatology 18, 125
Research Highlights | 01 February 2022

ALCAM–CD6 in lupus nephritis
- Susan Allison
Nature Reviews Nephrology 18, 137
Research Highlights | 20 September 2021

RBC mitochondria trigger interferon release
- Monica Wang
Nature Reviews Nephrology 17, 707

All News & Comment

Lupus nephritis

Latest Research and Reviews

Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis

CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis

CircRTN4 aggravates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis

A preliminary study of KAT2A on cGAS-related immunity in inflammation amplification of systemic lupus erythematosus

Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus

IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development

News and Comment

Treatment of SLE with anti-CD19 CAR-T cells

Determining treatment response in lupus nephritis

Interferon blockade in lupus: effects on antiviral immunity

CD6 is a therapeutic target for LN

ALCAM–CD6 in lupus nephritis

RBC mitochondria trigger interferon release

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