Live attenuated vaccines articles within Nature

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  • Article |

    Two malaria vaccines comprising Plasmodium falciparum sporozoites and treatment with either pyrimethamine or chloroquine induced durable protective responses against both the African vaccine strain and a heterologous South American strain of P. falciparum.

    • Agnes Mwakingwe-Omari
    • , Sara A. Healy
    •  & Patrick E. Duffy

  • Letter |

    Immunization with Plasmodium falciparum sporozoites under chemoprophylaxis can protect against controlled human malaria infection with the same strain for at least 10 weeks, and protection correlates with polyfunctional T-cell memory.

    • Benjamin Mordmüller
    • , Güzin Surat
    •  & Peter G. Kremsner

  • Letter |

    Cellular immune responses in rhesus macaques (Macaca mulatta) vaccinated with cytomegalovirus vectors expressing SIV proteins are able to stringently control highly pathogenic SIV infection, regardless of the route of challenge, after systemic spread; immunological and virological analyses of protected macaques followed for up to 3 years suggest that persistent immune surveillance by vaccine-elicited immune responses may have cleared the infection.

    • Scott G. Hansen
    • , Michael Piatak Jr
    •  & Louis J. Picker

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