Lipid signalling

Lipid signalling encompasses a diverse set of cell signalling events. Lipid second messengers, including phosphatidylinositols, sphingolipids and steroid hormones, bind to proteins to effect changes in their activity and localisation. Local production of lipids can also influence the membrane recruitment of proteins.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    The scavenger receptor class B member 1 (SRB1) in endothelial cells mediates active transcellular transport of circulating LDL into the artery wall and thereby drives the accumulation of LDL in macrophages, which become foam cells and promote the development of atherosclerosis

    • Irene Fernández-Ruiz
  • News and Views |

    Plant nutrient-uptake involves the growth and maintenance of viable root hairs that are flexible but resistant to soil hardening, water content variability and pathogen attack. A role for phosphoinositides establishing polarity and structural hardening of the cell wall is now defined, linking lipid signalling and membrane trafficking to cellular morphology.

    • Rui Malhó
    Nature Plants 4, 861-862
  • News and Views |

    Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.

    • Michael Ebner
    •  & Volker Haucke
    Nature Cell Biology 20, 994-995
  • Comments and Opinion |

    Anne Simonsen is a Professor at the Department of Molecular Medicine at the Institute of Basic Medical Sciences of the University of Oslo, Norway. Her work focuses on lipid-binding proteins in membrane trafficking and autophagy, and their links to disease.

    • Anne Simonsen
  • News and Views |

    Specific combinations of mutations cause unique signalling and metabolic requirements. Concurrent G-protein αs (GNAS) and KRAS mutations in a subset of pancreatic tumours are now shown to inhibit SIK kinases through aberrant cAMP–PKA activation, triggering a metabolic program defined by lipid metabolism and fatty acid oxidation.

    • Pablo E. Hollstein
    •  & Reuben J. Shaw
    Nature Cell Biology 20, 740-741