Ligases articles within Nature

Featured

• Article | 19 May 2021

  Discovery, characterization and engineering of ligases for amide synthesis

  A family of enzymes—coronafacic acid ligases, involved in the synthesis of bacterial phytotoxins—are found to catalyse amide bond formation with a wide range of substrates.

  • Michael Winn
  • , Michael Rowlinson
  •  & Jason Micklefield

• Article | 08 July 2020

  Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

  The E3 ubiquitin ligase TRIM7 polyubiquitinates the envelope protein of Zika virus, adding Lys63-linked polyubiquitin chains that interact with the TIM1 receptor of host cells to enhance virus entry and replication.

  • Maria I. Giraldo
  • , Hongjie Xia
  •  & Ricardo Rajsbaum

• Letter | 23 May 2018

  Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector

  Crystal structures of the Legionella effectors SdeA and SdeD uncover the mechanism of a unique phosphoribosyl-ubiquitination reaction.

  • Anil Akturk
  • , David J. Wasilko
  •  & Yuxin Mao

• Letter | 01 December 2011

  Image-based genome-wide siRNA screen identifies selective autophagy factors

  • Anthony Orvedahl
  • , Rhea Sumpter Jr.
  •  & Beth Levine

• Letter | 16 November 2011

  Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour

  Natural variation in hecw-1 encoding an E3 ubiquitin ligase influences the avoidance of pathogenic bacteria by Caenorhabditis elegans and forms a molecular basis for behavioural variation.

  • Howard C. Chang
  • , Jennifer Paek
  •  & Dennis H. Kim

• News & Views | 02 March 2011

  The expanding arena of DNA repair

  The protein Sae2 mediates the repair of double-strand breaks in DNA. It emerges that Sae2 activity is controlled by both its modification with acetyl groups and its degradation by the process of autophagy. See Article p.74

  • Catherine J. Potenski
  •  & Hannah L. Klein