Invadopodia articles within Nature Communications

Featured

  • Article
    | Open Access

    The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to invade.

    • Robin Ferrari
    • , Gaëlle Martin
    •  & Philippe Chavrier

  • Article
    | Open Access

    In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can migrate through confining matrices using force generation alone, rather than protease degradation, if the matrices exhibit mechanical plasticity.

    • Katrina M. Wisdom
    • , Kolade Adebowale
    •  & Ovijit Chaudhuri

  • Article
    | Open Access

    The ability of cancer cells to migrate through small, constricted areas is limited by nuclear stiffness. Here the authors show that in turn nuclear stiffness stimulates the delivery of enzymes important for the degradation of the extracellular matrix and the formation of invadopodia in association with fibers thus opposing nuclear movement.

    • Elvira Infante
    • , Alessia Castagnino
    •  & Philippe Chavrier

  • Article
    | Open Access

    Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their structure.

    • Zakaria Ezzoukhry
    • , Elodie Henriet
    •  & Frédéric Saltel

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