Information theory

  • Article
    | Open Access

    Understanding how cells discriminate between stimuli is an ongoing challenge. Here, the authors propose a mathematical framework for inferring the mutual information encoded in temporal signaling dynamics and use it to study how information is transmitted over time in response to different stimuli in NFκB, MAPK and p53 signaling pathways.

    • Ying Tang
    • , Adewunmi Adelaja
    •  & Alexander Hoffmann
  • Article
    | Open Access

    Current synthetic DNA-based data storage systems have high recording costs, read-write latency and error-rates that make them uncompetitive compared to traditional digital storage. The authors use nicks in native DNA to encode data in parallel and create access sites for in-memory computations.

    • S. Kasra Tabatabaei
    • , Boya Wang
    •  & Olgica Milenkovic
  • Article
    | Open Access

    Model-based centralization schemes, though able to quantify locomotion control in animals and bio-inspired robots, are limited to specific systems. Here, the authors report a generalized information-based centralization scheme that unifies existing models and can be applied to different systems.

    • Izaak D. Neveln
    • , Amoolya Tirumalai
    •  & Simon Sponberg
  • Article
    | Open Access

    G protein-coupled receptors (GPCRs) activate intracellular signalling pathways upon extracellular stimulation. Here authors record single cell responses of GPCR signalling which allows the direct estimation of its channel capacity for each cell along with the reproducibility of its response.

    • Amiran Keshelava
    • , Gonzalo P. Solis
    •  & Vladimir L. Katanaev