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TLR7 gain-of-function genetic variation causes human lupus
The missense TLR7Y264H gain-of-function genetic variation causes systemic lupus erythematosus in humans and mice.
- Grant J. Brown
- , Pablo F. Cañete
- & Carola G. Vinuesa
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Article |
Local immune response to food antigens drives meal-induced abdominal pain
In mice, oral tolerance to food antigens can break down after enteric infection, and this leads to food-induced pain resembling irritable bowel syndrome in humans.
- Javier Aguilera-Lizarraga
- , Morgane V. Florens
- & Guy E. Boeckxstaens
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Outlook |
Adoptive cell therapy: Honing that killer instinct
Genetically altered immune cells are helping to push life-threatening cancers into remission and generating a buzz.
- Courtney Humphries
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Letter |
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Alzheimer’s-prone mice deficient in NLRP3 or caspase-1 fail to develop learning deficits and show reduced neuropathology.
- Michael T. Heneka
- , Markus P. Kummer
- & Douglas T. Golenbock
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Letter |
Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
B-cell receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL) is found not to be dependent on exogenous antigens; instead, signalling may involve the binding of the BCR heavy-chain complementarity-determining region to self epitopes on the same receptor, a finding that may have important implications for understanding the pathogenesis of CLL and potential therapeutic approaches.
- Marcus Dühren-von Minden
- , Rudolf Übelhart
- & Hassan Jumaa
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Article |
Myocardial infarction accelerates atherosclerosis
Myocardial infarction accelerates atherosclerosis through activation of the sympathetic nervous system, and the consequent release of haematopoietic stem and progenitor cells.
- Partha Dutta
- , Gabriel Courties
- & Matthias Nahrendorf
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Perspective |
Allergic host defences
A review of allergic host defences argues that allergic immunity has an important role in host defence against noxious environmental substances.
- Noah W. Palm
- , Rachel K. Rosenstein
- & Ruslan Medzhitov
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Letter |
Clonal selection drives genetic divergence of metastatic medulloblastoma
In a mouse model and in human medulloblastoma patients, the metastases in an individual have similar genomic alterations and DNA methylation patterns, but these patterns are highly divergent from those of the primary tumour, indicating that therapies will need to be tailored to fit the molecular alterations present in the primary tumour and/or the metastases.
- Xiaochong Wu
- , Paul A. Northcott
- & Michael D. Taylor
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Letter |
Outgrowth of single oncogene-expressing cells from suppressive epithelial environments
The earliest stages of tumorigenesis are mimicked in a three-dimensional model of mammary epithelial cells, showing that oncogenes that can promote cell translocation can also drive clonal outgrowth.
- Cheuk T. Leung
- & Joan S. Brugge
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Review Article |
Inflammasomes in health and disease
- Till Strowig
- , Jorge Henao-Mejia
- & Richard Flavell
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Outlook |
Treatment: In search of a booster shot
A plethora of therapies can keep the symptoms of allergy under control, but they can't cure. New research aims to prevent allergies from developing in the first place.
- Lauren Gravitz
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Correspondence |
Nobels: Toll pioneers deserve recognition
- James P. Allison
- , Christophe Benoist
- & Alexander V. Chervonsky
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Article |
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
- David Weismann
- , Karsten Hartvigsen
- & Christoph J. Binder
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News & Views |
Recognition of a unique partner
The mammalian immune system can fight a myriad of pathogens. In part, this involves a superfamily of cytoplasmic receptors that dictate assembly of specific pro-inflammatory inflammasome complexes. See Letters p.592 & p.596
- Denise M. Monack
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News |
Antibodies linked to long-term Lyme symptoms
Researchers find molecules that might mark elusive syndrome.
- Amy Maxmen
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Letter |
Control of TH17 cells occurs in the small intestine
- Enric Esplugues
- , Samuel Huber
- & Richard A. Flavell
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Review Article |
Intestinal homeostasis and its breakdown in inflammatory bowel disease
- Kevin J. Maloy
- & Fiona Powrie
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Letter |
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- Bin-Zhi Qian
- , Jiufeng Li
- & Jeffrey W. Pollard
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Review Article |
Progress and challenges in translating the biology of atherosclerosis
- Peter Libby
- , Paul M Ridker
- & Göran K. Hansson
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Letter |
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
The genetic basis of alopecia areata, one of the most common human autoimmune diseases, is largely unknown. This study reports a genome-wide association for this trait that implies the involvement of acquired and innate immunity. Among significant associations are the cytomegalovirus UL16-binding protein genes, which encode activating ligands for the natural killer cell receptor, NKG2D, here implicated for the first time in any autoimmune disease.
- Lynn Petukhova
- , Madeleine Duvic
- & Angela M. Christiano
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Letter |
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Severe trauma can lead to death and sepsis in the absence of apparent infection. Here evidence shows that mitochondrial debris, released from damaged cells, is present in the circulation of seriously injured trauma patients. Such debris is shown to activate neutrophils via specific formyl peptide receptors, triggering systemic inflammation and end organ injury.
- Qin Zhang
- , Mustafa Raoof
- & Carl J. Hauser
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance