Immunological models

Immunological models are experimental systems that recreate aspects of the human immune system to study its development and function in health and disease. The most common are transgenic or genetic mouse models with altered immunity.

Latest Research and Reviews

News and Comment

  • Comments and Opinion |

    Quorum sensing is the regulation of gene expression programmes in response to changes in population density. It is probably best recognized as a mechanism through which bacterial communities can synchronize behaviours, such as biofilm formation and bioluminescence. This Comment article highlights the emerging evidence suggesting that quorum sensing also contributes to the regulation of immune cell responses.

    • Luca Antonioli
    • , Corrado Blandizzi
    • , Pál Pacher
    • , Martin Guilliams
    •  & György Haskó
  • Comments and Opinion |

    Here, the authors present a new theoretical framework — the discontinuity theory — to account for how the immune system generates an appropriate immune response to any perceived disturbance. On the the basis of this theory, the authors present a mathematical model and provide examples to explain how this model can account for diverse immune responses.

    • Thomas Pradeu
    • , Sébastien Jaeger
    •  & Eric Vivier