Immunological disorders

A vaccine based on liposome-formulated uracil-modified mRNA shows promise in mouse models of multiple sclerosis.

A recent study in Science Immunology describes a new approach to selectively eliminate pathogenic CD4⁺ T cells in inflammatory bowel disease by activating them in the presence of metabolic checkpoint inhibition.

A new study shows successful immunotherapy of a detrimental gastrointestinal disease using the complement inhibitor eculizumab.

Genetic variation contributes to immune cell function. An unprecedented analysis of genetic associations with immune cell traits provides insights into the complex regulation of immune cells, reveals variants that coincidently influence immune traits and autoimmune disease risk, and offers specific therapeutic targets for these diseases.

A new study identifies the mitochondrial protein ALDH4A1 as a potential biomarker of atherosclerosis and as a target antigen of protective autoantibody A12, which might have therapeutic potential.