Imaging articles within Nature Reviews Genetics

Featured

  • Review Article |

    In this Review, Hwang and co-authors outline single-molecule fluorescence imaging techniques that can be used in living cells to visualize individual molecules involved in the spatiotemporal regulation of gene expression. This Review also delves into the biological insights gained through these methodologies.

    • Dong-Woo Hwang
    • , Anna Maekiniemi
    •  & Hanae Sato

  • Research Highlight |

    A study in Molecular Cell reveals how CTCF and cohesin contribute to genome organization through their roles in forming and stacking chromatin loops.

    • Dorothy Clyde

  • Review Article |

    In this Review, the authors discuss our latest understanding of the spatial aspects of cancer evolution, including the roles of cancer subclonal structure, tissue architecture, and interactions between cancer cells and diverse cell types of the microenvironment at local and distant sites.

    • Zaira Seferbekova
    • , Artem Lomakin
    •  & Moritz Gerstung

  • Research Highlight |

    A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes to be assessed at remarkable phenotypic depth.

    • Dorothy Clyde

  • Review Article |

    This Review discusses how chromosome tracing has deepened our understanding of the role of 3D chromatin topology in transcriptional regulation by helping to resolve open questions and opposing models rising from data generated by sequencing-based approaches, such as 3C and HiC.

    • Antonina Hafner
    •  & Alistair Boettiger

  • In Brief |

    In a report in Molecular Cell, Wang et al. describe genome oligopaint via local denaturation fluorescence in situ hybridization (GOLD FISH). This Cas9-superhelicase-based DNA-FISH method locally denatures DNA at physiological temperatures and provides an improved signal-to-background ratio.

    • Dorothy Clyde

  • Research Highlight |

    A recent study in Nature presents a method that integrates data from chromosome imaging, nuclear bodies and chromatin states to build a picture of the nuclear layout at the single-cell level.

    • Ingrid Knarston

  • Research Highlight |

    A report in Science describes in situ genome sequencing (IGS), a method that enables genomes to be simultaneously sequenced and imaged in intact samples, including early mouse embryos. IGS will facilitate insight into the relationship between genome sequence and organization.

    • Dorothy Clyde

  • Research Highlight |

    A new study in Science reports a synthetic biology approach to encode an ultrasound-based gene expression reporter that is applicable to mammalian cells in vitro and in vivo.

    • Darren J. Burgess

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