Hypoxic–ischaemic encephalopathy articles within Nature Communications

Featured

• Article
  08 August 2023 | Open Access

  Mechanisms underlying pathological cortical bursts during metabolic depletion

  Disruption to the brain’s oxygen supply triggers pathological dynamics and brain injuries. Here, the authors develop a model of coupled metabolic-neuronal activity that generates burst suppression patterns similar to those of infants after birth asphyxia.

  • Shrey Dutta
  • , Kartik K. Iyer
  •  & James A. Roberts

• Article
  10 November 2022 | Open Access

  Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice

  OPC-vascular coupling contributes to myelin maintenance. Here the authors show Cav-1 stabilizes interactions and mediates OPC maturation in ischemia.

  • Ying Zhao
  • , Wusheng Zhu
  •  & Xinfeng Liu

• Article
  01 April 2022 | Open Access

  Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

  COVID-19 can result in neurological manifestations and animal models could provide insights into the mechanisms. Here, the authors describe neuroinflammation, microhemorrhages and brain hypoxia in SARS-CoV-2 infected non-human primates, including in animals that don’t develop severe respiratory disease.

  • Ibolya Rutkai
  • , Meredith G. Mayer
  •  & Tracy Fischer

• Article
  20 March 2015 | Open Access

  The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

  The targeting of inflammation has emerged as a promising therapeutic strategy for cerebral ischaemia. Here the authors show that TIM-3, a member of the T-cell immunoglobulin and mucin domain protein family, is upregulated in glial cells and plays a role in inflammation-associated brain injury under hypoxic conditions.

  • Han Seok Koh
  • , Chi Young Chang
  •  & Eun Jung Park