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Article
| Open Access
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
Naked mole-rats are hypoxia-tolerant mammals, and during hypoxia their body temperature decreases via unknown mechanisms. Here the authors report that the hypoxia-induced body temperature decrease in naked mole rats occurs through decreased brown adipose tissue thermogenesis via decreases in a key thermogenic mitochondrial protein: UCP1.
- Hang Cheng
- , Rajaa Sebaa
- & Matthew E. Pamenter
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Article
| Open Access
Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.
- Hajime Abe
- , Norihiko Takeda
- & Issei Komuro
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Article
| Open Access
Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow and gut microbiota. Here, the authors show that chronic hypoxia predisposes bone marrow stem cells to premature senescence, which may be due to gut dysbiosis and gut microbiota-derived d-galactose accumulation.
- Junyue Xing
- , Yongquan Ying
- & Hao Zhang
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Article
| Open Access
Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs
Hyperoxia contributes to lung injury in bronchopulmonary dysplasia. The authors show that hyperoxia increases miR-34a expression in human neonates and in mouse models, and that pathology is ameliorated by miR-34a inhibition or by administration of its target angiopoietin-1
- Mansoor Syed
- , Pragnya Das
- & Vineet Bhandari
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Article
| Open Access
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environments in mice and humans.
- Kaiqi Sun
- , Yujin Zhang
- & Yang Xia
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Article
| Open Access
Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells
Hypoxia promotes tumour aggressiveness and resistance of cancers to oncological treatment. Here, the authors show that caveolin-1 can down-regulate global membrane protein endocytosis in hypoxic cells with potential implications for targeting the hypoxic 3microenvironment of aggressive tumours.
- E. Bourseau-Guilmain
- , J. A. Menard
- & M. Belting
Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion