Hippocampus articles within Nature Communications

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  • Article
    | Open Access

    Memory representations in cortex and hippocampus are reactivated during sharp-wave ripple (SWR) events. Here, the authors show that, in a familiar environment, this activity preferentially links spatially selective hippocampal cells and task general PFC representations, pointing to a potential neural mechanism for generalization of individual experiences.

    • Jai Y. Yu
    • , Daniel F. Liu
    •  & Loren M. Frank

  • Article
    | Open Access

    Feeding-relevant vagal signaling occurs between the gastrointestinal tract and the brain, but it is unclear if this pathway influences cognitive processes. This study shows that endogenous gastrointestinal derived vagal sensory signaling promotes hippocampal-dependent memory function via a multi-order brainstem–septal pathway.

    • Andrea N. Suarez
    • , Ted M. Hsu
    •  & Scott E. Kanoski

  • Article
    | Open Access

    Detailed memories are transformed into gist-like memories over time. Here, the authors report that this change is linked to a time-dependent reorganization within the hippocampus, such that anterior activity supporting memory specificity declines over time while posterior activity patterns carrying gist representations remain more stable.

    • Lisa C. Dandolo
    •  & Lars Schwabe

  • Article
    | Open Access

    Odor-guided spatial behaviours are difficult to study due to the challenge of controlling chemical concentrations in space and time. Here the authors present a precise odor delivery system to generate a olfactory virtual landscape that engages hippocampal place cells in mice.

    • Brad A. Radvansky
    •  & Daniel A. Dombeck

  • Article
    | Open Access

    Computational studies have hinted that hippocampal subfields represent information differently. Here, the authors show that when retrieving items that share an episodic context, subfield CA1 represent similarities between items whereas CA2/3/dentate gyrus represents item-unique features.

    • Halle R. Dimsdale-Zucker
    • , Maureen Ritchey
    •  & Charan Ranganath

  • Article
    | Open Access

    Previous work has documented a slow form of memory generalization although a rapid one is demanded. Here the authors elucidate the role of the interhemispheric CA1-CA1 projection in a form of rapid generalization of contextual fear memory via gradual potentiation of these synapses over 24 h.

    • Heng Zhou
    • , Gui-Jing Xiong
    •  & Lin Xu

  • Article
    | Open Access

    Changes to subsets of dendritic spines are thought to be important for memory formation. Here, the authors develop a hybrid RNA/protein tool that allows for optogenetic stimulation of single synapses that have been tagged in an activity-dependent manner

    • Francesco Gobbo
    • , Laura Marchetti
    •  & Antonino Cattaneo

  • Article
    | Open Access

    The APOE4 allele is the leading risk factor for late-onset Alzheimer’s disease, but how it might contribute to the disease is not clear. Here the authors show that a mouse expressing the human APOE4 allele displays hyperactivity in the entorhinal cortex due to a decreased inhibitory tone, which may in part explain accelerated Alzheimer’s pathology in APOE4 carriers.

    • Tal Nuriel
    • , Sergio L. Angulo
    •  & Karen E. Duff

  • Article
    | Open Access

    Supramammillary nucleus (SuM) neurons have been studied in the context of REM sleep but their possible role in mediating wakefulness is not known. Here the authors elucidate the distinct functional contributions of three subpopulations in the SuM on electrographical and behavioral arousal in mice using genetically targeted approaches.

    • Nigel P. Pedersen
    • , Loris Ferrari
    •  & Patrick M. Fuller

  • Article
    | Open Access

    Though people are easily able to recall items in a category without mentioning a wrong exemplar, the mechanism underlying this ability is unknown. Here, authors use intracranial recordings to show that this ability is likely due to a selective increase in baseline neuronal activity in category-specific regions.

    • Yitzhak Norman
    • , Erin M. Yeagle
    •  & Rafael Malach

  • Article
    | Open Access

    It is not fully understood how intrusive or unwanted memories are regulated. Here the authors show that hippocampal GABA concentrations, and coupling between the dorsolateral prefrontal cortex and hippocampus, predict how well subjects can suppress unwanted memories when presented with a reminder.

    • Taylor W. Schmitz
    • , Marta M. Correia
    •  & Michael C. Anderson

  • Article
    | Open Access

    Neurons in the retrosplenial cortex (RSC) encode spatial and navigational signals. Here the authors use calcium imaging to show that, similar to the hippocampus, RSC neurons also encode place cell-like activity in a sparse orthogonal representation, partially anchored to the allocentric cues on the linear track.

    • Dun Mao
    • , Steffen Kandler
    •  & Vincent Bonin

  • Article
    | Open Access

    Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST+ interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY+ hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.

    • Syed Ahsan Raza
    • , Anne Albrecht
    •  & Oliver Stork

  • Article
    | Open Access

    The hippocampus is known to support navigation, but how it processes possible paths to aid navigation is unknown. Here Javadiet al. show that entering streets drives hippocampal activity corresponding to the number of future paths, and that prefrontal activity corresponds to path-planning demands.

    • Amir-Homayoun Javadi
    • , Beatrix Emo
    •  & Hugo J. Spiers

  • Article
    | Open Access

    Amygdala and hippocampus are involved in processing motivationally salient stimuli but the precise circuit dynamics of the interaction is not understood. Here the authors show that in response to fearful faces in humans, theta/alpha oscillations in the amygdala modulate hippocampal activity dynamics.

    • Jie Zheng
    • , Kristopher L. Anderson
    •  & Jack J. Lin

  • Article
    | Open Access

    Short-term memories (STM) can become long-term memories when occurring alongside novel experiences. Here, the authors investigate the neural mechanisms behind such 'behavioural tagging' and find STM neural populations are preferentially incorporated into the ensembles encoding novel experiences.

    • Masanori Nomoto
    • , Noriaki Ohkawa
    •  & Kaoru Inokuchi

  • Article
    | Open Access

    The ability to form associations between events is the hallmark of episodic memory and is thought to involve the hippocampus. Here the authors use a combination of multivariate pattern and graph theoretical network analyses of functional imaging data in humans, and show conjunctive coding and hub-like network attributes in the hippocampus.

    • Alexander R. Backus
    • , Sander E. Bosch
    •  & Christian F. Doeller

  • Article
    | Open Access

    Place cells in hippocampus encode a map of space, however the role of activity in place map stability is not known. Schoenenberger and colleagues optogenetically manipulate hippocampal firing rates within place fields and show lasting changes in spatial firing patterns through two separate mechanisms.

    • Philipp Schoenenberger
    • , Joseph O’Neill
    •  & Jozsef Csicsvari

  • Article
    | Open Access

    STDP is dependent on the timing of pre- and post-synaptic activity. Here, the authors describe a symmetric STDP induction rule at CA3-CA3 synapses, which induces LTP over a broad range of paring intervals. Modelling suggests that this STDP rule may enhance storage capacity and pattern completion in the CA3 cell network.

    • Rajiv K. Mishra
    • , Sooyun Kim
    •  & Peter Jonas

  • Article
    | Open Access

    There is limited evidence linking learning related changes in hippocampal representations and memory interference. Here Favila and colleagues demonstrate that learning reduces overlap in hippocampal activity patterns corresponding to similar events, which benefits subsequent learning by preventing interference.

    • Serra E. Favila
    • , Avi J. H. Chanales
    •  & Brice A. Kuhl

  • Article
    | Open Access

    Dentate gyrus (DG) is critical for memory formation in the hippocampus but its role in memory retrieval is unclear. Here, Gross and colleagues, show that granule cells in DG are not required for memory retrieval but for maintenance, and inhibiting them with a drug leads to rapid loss of memory.

    • Noelia Madroñal
    • , José M. Delgado-García
    •  & Agnès Gruart

  • Article
    | Open Access

    Suppressing an unwanted memory reduces hippocampal activity and makes people more likely to forget the experience. Here, the authors show that suppressing past events induces an "amnesic shadow" for experiences near in time to suppression, consistent with a global disruption to hippocampal function.

    • Justin C. Hulbert
    • , Richard N. Henson
    •  & Michael C. Anderson

  • Article
    | Open Access

    New neurons are continuously produced throughout adulthood in the hippocampus. Here the authors provide evidence that adult hippocampal neurogenesis weakens existing memories, and facilitates the encoding of new, confliction information in mice.

    • Jonathan R. Epp
    • , Rudy Silva Mera
    •  & Paul W. Frankland

  • Article
    | Open Access

    Recent work has implicated hippocampal subfield CA2 in encoding social and contextual memory yet the neural mechanisms are not known. Here, Alexander and colleagues demonstrate that, compared to CA1 neurons, CA2 neurons modify their place fields when presented with social or novel stimuli.

    • Georgia M. Alexander
    • , Shannon Farris
    •  & Serena M. Dudek

  • Article
    | Open Access

    During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated activation of NMDARs and VGCCs and their regulation by mGluRs and SK channels.

    • Cezar M. Tigaret
    • , Valeria Olivo
    •  & Jack R. Mellor

  • Article
    | Open Access

    The ventral hippocampus connects to the hypothalamus and has been implicated in feeding behaviours. Here, the authors use a combination of optogenetics and DREADD strategies to dissect the underlying circuit, showing that projections from the vHC to the lateral septum work to regulate feeding suppression.

    • Patrick Sweeney
    •  & Yunlei Yang

  • Article
    | Open Access

    Amyloid-beta deposits are a pathological hallmark of Alzheimer’s disease, and have previously been targeted in immunisation therapies. Here, the authors show that oral administration of the small molecule EPPS reduces Aß plaque and oligomer load in APP/PS1 mice and improves learning and memory performance.

    • Hye Yun Kim
    • , Hyunjin Vincent Kim
    •  & YoungSoo Kim

  • Article
    | Open Access

    Understanding how ß-amyloid contributes to synapse loss and dysfunction is a central goal of Alzheimer’s disease research. Here, Leshchyns’ka et al.identify a novel mechanism by which Aß disassembles hippocampal glutamatergic synapses via cleavage of a neural cell adhesion molecule 2 (NCAM2).

    • Iryna Leshchyns’ka
    • , Heng Tai Liew
    •  & Vladimir Sytnyk

  • Article
    | Open Access

    In vitro differentiation of human pluripotent stem cells (hPSCs) has enabled the generation of neuroectodermal tissues. Here, Sakaguchi et al.use a modified neocortical induction method to generate functional hippocampal granule and pyramidal-like neurons, as well as dorsomedial telencephalic tissues from hPSCs.

    • Hideya Sakaguchi
    • , Taisuke Kadoshima
    •  & Yoshiki Sasai

  • Article
    | Open Access

    Hippocampal theta oscillations support encoding of spatial information during navigation, yet their role in locomotion is poorly understood. Here the authors demonstrate that hippocampal theta oscillations regulate the speed of locomotion in rodents through a hippocampo-lateral septal-hypothalamic pathway.

    • Franziska Bender
    • , Maria Gorbati
    •  & Alexey Ponomarenko

  • Article
    | Open Access

    Adult hippocampal neurogenesis is involved in the response to stress but whether it exerts a positive or negative effect remains unclear. Here the authors ablate hippocampal neurogenesis in mice and find that the effects on anxiety behaviour depend on the time of day, and that neurogenesis specifically impairs the response to stress during the dark cycle.

    • Cheng-Yu Tsai
    • , Ching-Yen Tsai
    •  & Guo-Jen Huang

  • Article
    | Open Access

    Selective biallelic expression of certain genes through genomic imprinting are known to play a role in controlling neurogenesis in the adult mammalian brain. Here the authors investigate the role of imprinting in the dosage control of Igf2 and its relevance for the function of IGF2 as a neurogenic regulator in the mouse brain.

    • S. R. Ferrón
    • , E. J. Radford
    •  & A. C. Ferguson-Smith

  • Article
    | Open Access

    Our memory system maintains flexibility by representing both specific events as well as generalizations across events, yet the brain regions supporting each remain unknown. Here the authors reveal dissociable neural signatures of memory separation and integration in the hippocampus and prefrontal cortex.

    • Margaret L. Schlichting
    • , Jeanette A. Mumford
    •  & Alison R. Preston

  • Article
    | Open Access

    Recalled memories enter a labile state and are thought to be restabilized through reconsolidation. Here, the authors challenge the long-held notion that reconsolidation is a distinct memory process and demonstrate that the molecular events initiated at recall act instead to constrain premature extinction.

    • Simon Trent
    • , Philip Barnes
    •  & Kerrie L. Thomas

  • Article
    | Open Access

    The holistic retrieval of complex event memories is thought to be the hallmark of episodic memory. Here, the authors provide behavioural and neuroimaging evidence that the hippocampus binds together the elements forming an event to allow holistic episodic recollection via pattern completion of all elements.

    • Aidan J. Horner
    • , James A. Bisby
    •  & Neil Burgess

  • Article
    | Open Access

    Enhanced glutamatergic transmission in the nucleus accumbens (NAc) has been implicated in the pathophysiology of depression, yet the underlying source is not known. Here, the authors demonstrate a unique role for ventral hippocampal-NAc glutamatergic projections in regulating depression-like behaviour.

    • Rosemary C. Bagot
    • , Eric M. Parise
    •  & Eric J. Nestler

  • Article
    | Open Access

    Aberrant hippocampal neurogenesis often occurs after acute seizures that produce epilepsy and cognitive impairment but the role of neurogenesis in the development of epilepsy is unclear. Here the authors suppress adult neurogenesis in mice preceding seizures and show that it reduces subsequent chronic seizure frequency and epilepsy-associated cognitive decline.

    • Kyung-Ok Cho
    • , Zane R. Lybrand
    •  & Jenny Hsieh

  • Article
    | Open Access

    Epileptic seizures generate aberrant neurogenesis in the adult mouse hippocampal region but how animals cope with abnormal neurogenesis remains unknown. Here the authors show that microglia are activated through TLR9 signaling and that this leads to sustained expression of TNF-α which attenuates induced aberrant neurogenesis.

    • Taito Matsuda
    • , Naoya Murao
    •  & Kinichi Nakashima

  • Article |

    Several K+ channels control neuronal excitability, but the function of KCNQ5 (Kv7.5), which displays wide expression in the brain, is not known. Here the authors show that KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition.

    • Pawel Fidzinski
    • , Tatiana Korotkova
    •  & Thomas J. Jentsch

  • Article |

    Neurological disorders such as temporal lobe epilepsy (TLE) are known to be regulated by gene networks. In this study, the authors describe a genome-wide approach that uses samples of hippocampal tissue from patients with TLE, to identify the gene Sestrin 3 (SESN3) as a positive regulator of the disease.

    • Michael R. Johnson
    • , Jacques Behmoaras
    •  & Enrico Petretto

  • Article |

    The intracellular redox protein MICAL plays an important role during Drosophilanervous system development but the function of its vertebrate homologue remains unknown. Here the authors show that MICAL-1 regulates targeting of secretory vesicles containing IgCAMs to the neuronal growth cone in mice and plays a role in hippocampal connectivity.

    • Eljo Y. Van Battum
    • , Rou-Afza F. Gunput
    •  & R. Jeroen Pasterkamp

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