Haematopoietic cell growth factors articles within Nature Communications

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• Article
  03 February 2022 | Open Access

  Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation

  In the bone marrow, dendritic cell development is governed by supporting cells, such as endothelial cells. Here authors show that expression of serine/threonine kinase 11 in endothelial cells regulates differentiation of dendritic cell precursors via modulating secretion of stem cell factor.

  • Qiang Zhao
  • , Young-Min Han
  •  & Ming-Hui Zou

• Article
  09 January 2020 | Open Access

  GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

  Spondyloarthritis pathology is manifested by increased myeloid infiltration of the joints. Here the authors show that in a mouse model of spondyloarthritis, a single dose of a microbial ligand curdlan induces persistent extramedullary myelopoiesis in the spleen and joints, which is driven by GM-CSF and can be amplified by exogenous IL-33.

  • Daniel Regan-Komito
  • , James W. Swann
  •  & Thibault Griseri

• Article
  29 August 2018 | Open Access

  P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

  Erythropoietin (EPO) stimulates erythropoiesis and is commonly used to treat anemia. Here Hu et al. find that P38α/JNK signaling restrains erythropoiesis independently of EPO by regulating epigenetic silencing of the proapoptotic protein Bim, and thus identify putative targets for the treatment of anemic disorders resistant to EPO.

  • Ping Hu
  • , Angel R. Nebreda
  •  & Reuben Kapur

• Article
  10 April 2018 | Open Access

  Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo

  Delivery of therapeutic proteins to patients may be costly to administer, and often requires repeated injections. Here, the authors use antigen-specific T cells expressing erythropoietin, and show that following transfer in mice, cell expansion and erythropoietin production can be boosted by vaccination, raising the haematocrit.

  • Richard T. O’Neil
  • , Sunandan Saha
  •  & Matthew H. Wilson

• Article | 01 November 2011

  Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production

  Erythropoietin circulates in the blood and is essential for erythropoiesis but its role in metabolic homeostasis has not been examined. Tenget al. show that when the erythropoietin receptor is only expressed in erthyroid cells, mice develop obesity and insulin resistance, suggesting that the receptor has a key role in fat mass accumulation.

  • Ruifeng Teng
  • , Oksana Gavrilova
  •  & Constance Tom Noguchi