Graft-versus-host disease articles within Nature Communications

Featured

• Article
  29 March 2024 | Open Access

  Secondary bone marrow graft loss after third-party virus-specific T cell infusion: Case report of a rare complication

  Infusion of virus-specific T (VST) cells is used for treating drug-resistant viremia. Here the authors report, as part of the clinical trial, NCT03475212, a lethal case of unexpected bone marrow graft loss and chimerism reversal that is induced by the infusion of third-party VST intended to treat transplantation-related cytomegalovirus viremia.

  • Michael D. Keller
  • , Stefan A. Schattgen
  •  & Catherine M. Bollard

• Article
  10 January 2024 | Open Access

  ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

  Steroid-refractory acute graft-versus-host disease (aGVHD) is associated with a low one-year survival rate. Here, the authors show that ROCK1 is upregulated in leukocytes from patients with steroid-refractory aGVHD and that ROCK1/2 inhibition reduces the severity of aGVHD in mice by interfering with activation of multiple immune cell types.

  • Kristina Maas-Bauer
  • , Anna-Verena Stell
  •  & Robert Zeiser

• Article
  28 November 2023 | Open Access

  Data-driven grading of acute graft-versus-host disease

  Acute GVHD severity grading is based on target organ assessments. Here, the authors show that data-driven grading can identify 12 distinct grades with specific aGVHD phenotypes, which are associated with clinical outcomes, and that their method outperformed conventional gradings.

  • Evren Bayraktar
  • , Theresa Graf
  •  & Amin T. Turki

• Article
  21 March 2023 | Open Access

  Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy

  Immune checkpoint inhibitors (ICI) may have unanticipated side effects in transplant recipients who subsequently develop tumors. Here the authors used single-cell sequencing to identify and characterize allogeneic reactive T cells that developed after an ICI course for melanoma in a transplant recipient.

  • Garrett S. Dunlap
  • , Daniel DiToro
  •  & Deepak A. Rao

• Article
  23 June 2021 | Open Access

  Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human T_reg compartment

  Human Treg cells are central to immune tolerance, yet their heterogeneity and differentiation remain incompletely understood. Here the authors perform single-cell RNA and T cell receptor sequencing to resolve Treg cells from healthy individuals and patients with or without acute graft-versus-host disease revealing Treg complexity in health and disease.

  • Yuechen Luo
  • , Changlu Xu
  •  & Xiaoming Feng

• Article
  05 February 2021 | Open Access

  IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

  Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1^hi mononuclear phagocytes resulted from the reduction of Th/Tc1, contributes to SR-Gut-aGVHD onset.

  • Qingxiao Song
  • , Xiaoning Wang
  •  & Defu Zeng

• Article
  04 January 2021 | Open Access

  Longitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease

  Fecal microbiota transplant (FMT) is emerging as a potential treatment for graft-versus-host disease (GvHD). Here, the authors examine temporal dynamics of the bacteriome, mycobiome, and virome of a patient with GvHD who received multiple FMTs.

  • Fen Zhang
  • , Tao Zuo
  •  & Siew C. Ng

• Article
  07 May 2020 | Open Access

  Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease

  Chronic graft versus host disease (cGvHD) is a major cause of morbidity and mortality in allogeneic bone marrow transplantation. Here the authors identify a recurrent activating mTOR mutation in expanded donor T-cell clones of 3 cGvHD patients, which suggests somatic mutations may contribute to GvHD pathogenesis and opens avenues to targeted therapies.

  • Daehong Kim
  • , Giljun Park
  •  & Satu Mustjoki

• Article
  10 September 2018 | Open Access

  Microbial metabolite sensor GPR43 controls severity of experimental GVHD

  The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD.

  • Hideaki Fujiwara
  • , Melissa D. Docampo
  •  & Pavan Reddy

• Article
  21 August 2017 | Open Access

  Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

  Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand T_reg cells, mitigating the disease in mice.

  • Satish Ranjan
  • , Alexander Goihl
  •  & Berend Isermann